ID A0A0Q9YPI5_9COXI Unreviewed; 926 AA.
AC A0A0Q9YPI5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=RasGEF domain protein {ECO:0000313|EMBL:KRG22719.1};
GN ORFNames=HT99x_00259 {ECO:0000313|EMBL:KRG22719.1};
OS Candidatus Berkiella aquae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Berkiella.
OX NCBI_TaxID=295108 {ECO:0000313|EMBL:KRG22719.1, ECO:0000313|Proteomes:UP000051497};
RN [1] {ECO:0000313|EMBL:KRG22719.1, ECO:0000313|Proteomes:UP000051497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HT99 {ECO:0000313|EMBL:KRG22719.1,
RC ECO:0000313|Proteomes:UP000051497};
RA Mehari Y.T., Arivett B.A., Farone A.L., Gunderson J.H., Farone M.B.;
RT "Draft Genome Sequences of Two Novel Amoeba-resistant Intranuclear
RT Bacteria, Candidatus Berkiella cookevillensis and Candidatus Berkiella
RT aquae.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRG22719.1}.
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DR EMBL; LKAJ01000001; KRG22719.1; -; Genomic_DNA.
DR RefSeq; WP_075064904.1; NZ_LKAJ02000001.1.
DR AlphaFoldDB; A0A0Q9YPI5; -.
DR STRING; 295108.HT99x_00259; -.
DR OrthoDB; 5649125at2; -.
DR Proteomes; UP000051497; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000051497}.
FT REPEAT 110..142
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 543..773
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 926 AA; 105986 MW; 8826B83E83F8C823 CRC64;
MISGSDDGQV IKLKELFEKH EEKAIWDFIK KNPEAVNCRF LVERNILQMA ITKKMPLLIE
KLITNHPKLI HEFDRIHQGI FHHAVNCYDP HIMQMLITAA PELINHQRQD GKTALHLAMN
AQNELAVQQL VLAKANIYIA DIQEITPYSL VNGNPILLKA MCCWSQVLQP PPQEEPLSEV
IINDIKNLSR KFALLKINPV KPLTDPTISA DRFRTSIIMD KVDTSLSLEM IDDWDVIKLK
EYLTEGGDPN ILVIFGRPLI LHLFLRATTQ CSKTDDYDCM EAQLFYLLLK HALLDKSGSN
ANQCIQEHLV ENAPVKMQLL HHAQRHMSQE LGIMRTYYHQ QVKSLETEFD NILLFAGLHQ
LQRANQNNTK APNEVSELTR PQKILEKLCM GSMPYNKERT FNTRYISNMI NGLLSQTTAK
KMIAHIKKIW PNFDSEQKLI ANFIIKELVI IDFYRHSQTI DKKHILFLLE DNKKTFPLHA
PKLNAFFNNL FHFSDSMNKH PIYINHTLLE IWRRELIIAP SLTSFRELVT NATNSPLKAR
MAYVKQIANE INALTLAGYQ AIRIEELYDK KWSDINTQND APNIMRCIDI SNKLSFYIQE
MIVSAENVQA AARVFELFIL VAMELCTTNN HPGPNISAAF AIMNAFNTAV TGRLTKPLQA
IDKDIDKKLQ QLNKFAKPSK NFKWLRLTEL AHPTTLPYLG KMLSDVTFIY DGNPNLTMMC
EVLGSKLRQF SQLQRAISSV TSLPTTDIDQ FLGTHVFLNE DELYKRSCTL LPPDIMIDSL
SISQLINSIE RYIHKEILPH IIWKSKRFEG PAMINPICQC LGNHLQTMQK GATLKEDIVR
SKKMIGDLVS LINKHYPEAT LEYATYIAQI HELENMTDST VSDPNISISG SEALIFTSLE
ESATLPPQQL QKKHTLSFGN LRKSHK
//
