ID   A0A0R0LY68_9MICR        Unreviewed;      1291 AA.
AC   A0A0R0LY68;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=DsRNA-specific nuclease Dicer, ribonuclease {ECO:0000313|EMBL:KRH94138.1};
GN   ORFNames=M153_3720001104 {ECO:0000313|EMBL:KRH94138.1};
OS   Pseudoloma neurophilia.
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pseudoloma.
OX   NCBI_TaxID=146866 {ECO:0000313|EMBL:KRH94138.1, ECO:0000313|Proteomes:UP000051530};
RN   [1] {ECO:0000313|EMBL:KRH94138.1, ECO:0000313|Proteomes:UP000051530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MK1 {ECO:0000313|EMBL:KRH94138.1,
RC   ECO:0000313|Proteomes:UP000051530};
RA   Ndikumana S., Pelin A., Sanders J., Corradi N.;
RT   "The genome of Pseudoloma neurophilia, a relevant intracellular parasite of
RT   the zebrafish.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRH94138.1}.
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DR   EMBL; LGUB01000131; KRH94138.1; -; Genomic_DNA.
DR   VEuPathDB; MicrosporidiaDB:M153_3720001104; -.
DR   Proteomes; UP000051530; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   PANTHER; PTHR14950; DICER-RELATED; 1.
DR   PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF69065; RNase III domain-like; 2.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051530}.
FT   DOMAIN          802..976
FT                   /note="RNase III"
FT                   /evidence="ECO:0000259|PROSITE:PS50142"
FT   DOMAIN          1130..1260
FT                   /note="RNase III"
FT                   /evidence="ECO:0000259|PROSITE:PS50142"
FT   REGION          1059..1081
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1291 AA;  152167 MW;  07C08A987F72DA6B CRC64;
     MVPDCNSIFQ SDQQTDQIIA DICKKYEKVL LVVEDKNEEY QTNLDDFRSL NIHENTVSHR
     MITLRSMFFY LVRKGFLKAK DFDVCILRFK HLTKMEISTF QVFYRLNSDD SVNLRVYTFL
     DEIKDQDDIY LESKLYKKLD DLSDINKEKN VQMLYFTPEI TSKQRDYLQL KKILNFEDPQ
     NLEEISYKLV FKKIVQKIKI DKFSAKRSEN YKTVHVDEEK LRKISLNYLR LRMLKTILEQ
     NANKKIYVVC KRAILLNTIN FFNKYTENID LIIYFDIMDV DISASKAIFF IDFRTNIEDL
     AKITLKYDQT KNSSQFLTNV LDNKPEDAIR TEEGAYVEKS HSHVILNRIL TNIKHVFEQH
     LFFLSNLSYS DAYIMKGQNF KCFMKLPEIS DHSLFTRQFV SENMPSKKEA LHDVTFSILN
     QMLKEGCVSG NFVPNPEFFI LCDFYKTRLQ KTYDFNIELL QEFDREYLAN YKRVERAPFD
     YYIELLQDIE LKCRPKYFTK VYNWIFLLLR KFAKRYPNLN LRNKFKQKYM VTFKRENTII
     VKSRAIPRCF TSTESLHLFS IKSETFELGI LCGESFKGAF EFDGIKYRYI GKKRINVDEF
     NKIAMFNVVF FGINYKKRGM SSNYNYFVVP LQNDEIFVQK FVGDFYTNQN CTENLLFNPF
     NRNFYIFDSW VDKNAYKSIT YDHVNFTKKE SVNFEDSGKI PSQKIDETLV DSSEVDENVA
     VYDENNSRTI NQSDSQSSCP KDNLKIETCQ TYNIFEYFEQ RYAIKLQYTD QNAKNLMYLA
     KSYSRKMKDT QKFYFLTELT RVSPFKSNIA FQFDFFKNAF AYFEVLSLAA QAQQDMNLPI
     SVNLLSQCFM SKNDKYPNYE RYEFFGDCVL KYLVTKFFLI CYDKPIGTLV DTKCRIIRNS
     NLTRIGRKIS LESYFSNLLF QPPSLADATS KNLQDFFKFN HMGYNPSVAI NQELCTEKTY
     ADIIEAILGA CYLENGMEKT EKLIFDLEII QTNNYKLVDF KDENSEINTT EAVDSSLLDS
     KMSMSFGTNI NFVMSSSEED VDQILKNLDH DSMDVVNNSL LNSNNNEKQG KNQNGIDGNG
     ISKKAKTQFD APRFDIKRYL LCQNDPNYMF YNNFVRTAAS FTNAMKIEDI QKVEKILKYQ
     FKHKGFLEKA MIHPSSNTNI FGTRQYFEKL ELAGDSILDV LVTDEIFSSS SCPYELHEKR
     KDLVCNQIFG NVLFNSKLYK YAQTCFSHSD LVESHQHNSY KKIYGDIFEA INGAILLDCQ
     YDIHKFKEIW NKSIKKMLFD CFRIRASNQN Q
//