ID A0A0R1GWR9_9LACO Unreviewed; 817 AA.
AC A0A0R1GWR9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=FC07_GL000243 {ECO:0000313|EMBL:KRK35127.1};
OS Loigolactobacillus bifermentans DSM 20003.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Loigolactobacillus.
OX NCBI_TaxID=1423726 {ECO:0000313|EMBL:KRK35127.1, ECO:0000313|Proteomes:UP000051461};
RN [1] {ECO:0000313|EMBL:KRK35127.1, ECO:0000313|Proteomes:UP000051461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20003 {ECO:0000313|EMBL:KRK35127.1,
RC ECO:0000313|Proteomes:UP000051461};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRK35127.1}.
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DR EMBL; AZDA01000082; KRK35127.1; -; Genomic_DNA.
DR RefSeq; WP_057904800.1; NZ_AZDA01000082.1.
DR AlphaFoldDB; A0A0R1GWR9; -.
DR STRING; 1423726.FC07_GL000243; -.
DR PATRIC; fig|1423726.3.peg.252; -.
DR Proteomes; UP000051461; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13604; AAA_30; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}; Reference proteome {ECO:0000313|Proteomes:UP000051461}.
FT DOMAIN 356..514
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT BINDING 367..371
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 817 AA; 90852 MW; 2922D2CA3DBD82FD CRC64;
MATEMTLFPE EKAQPEVTGK VSAIFFQNPD NFYKVLLVQV EQVNFDWTDK EVVVTGSFGD
IKEEESYRFV GKMVTHPKYG MQFQASNYEK DQPTTKAGLI AYLAGDQFPG IGQKTAEKIV
SALGLDAIQK ILADPAVLKN LGIKTERIQT LVEQLTKNNG MDQIIIGLNS YGFGSQLAYT
IYEKYHEETL QVLAERPYQL VKDIPGIGFK KADQIAAQQH IAADAPERIQ AAILQEITEL
TQAEGDTYTQ AQPLLNATLN LLRESRQQAL SPDAVANQMI QLADQGDIIS EDNRIYLRQL
YRSEWKIAEN LQRLMKMVSL PDYDDAQVDR EIRRIEKLFK MTYGDSQIAT IKAALNSPVF
LLTGGPGTGK TTIINAIVLL FAKLNDLSLE LTDYKEKPFP ILLAAPTGRA AKRMSEVTGL
PASTIHRLLG LNGRENGDVI TKDLEGALLI IDEMSMVDTS LFRLLMQAVS NNMQVILVGD
RDQLPSVGPG QVFSDLLMSH ILPSSELTEI YRQDDGSSII PLAHAIKGGR LPADFTKNQK
DRSFIPCSAY QVAQAIDQIV TRAKSKGFTS QDIQVLAPMY RGAAGITKLN LEVQQILNPK
TGPRQKEITF RQQTFRVGDK VLHLVNSPEL NVFNGDIGEI VGVELAKDKG NEDKTDKLTI
RFDATEVTYG RNDWSKLTLA FCTSIHKAQG SEFKMVILPI VHQYQRMLQR NLLYTAITRA
QDLLILIGEQ DAFATAVAHE SINRKTTLQQ RLQTVFNGEQ PVQTPAKKEP AETVTATPVV
AMSEPDQTIL TTAMVEQRQV DPMIGMKNLT PQDFKTA
//
