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Database: UniProt
Entry: A0A0R1HHX5_9LACO
LinkDB: A0A0R1HHX5_9LACO
Original site: A0A0R1HHX5_9LACO 
ID   A0A0R1HHX5_9LACO        Unreviewed;       720 AA.
AC   A0A0R1HHX5;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Sulfatase family protein {ECO:0000313|EMBL:KRK46205.1};
GN   ORFNames=FC66_GL000707 {ECO:0000313|EMBL:KRK46205.1};
OS   Dellaglioa algida DSM 15638.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Dellaglioa.
OX   NCBI_TaxID=1423719 {ECO:0000313|EMBL:KRK46205.1, ECO:0000313|Proteomes:UP000051450};
RN   [1] {ECO:0000313|EMBL:KRK46205.1, ECO:0000313|Proteomes:UP000051450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15638 {ECO:0000313|EMBL:KRK46205.1,
RC   ECO:0000313|Proteomes:UP000051450};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004936}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the LTA synthase family.
CC       {ECO:0000256|ARBA:ARBA00009983}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRK46205.1}.
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DR   EMBL; AZDI01000002; KRK46205.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R1HHX5; -.
DR   STRING; 1423719.FC66_GL000707; -.
DR   PATRIC; fig|1423719.4.peg.717; -.
DR   Proteomes; UP000051450; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR   CDD; cd16015; LTA_synthase; 1.
DR   Gene3D; 3.30.1120.170; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR012160; LtaS-like.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR   PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051450};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        47..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        131..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          253..548
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   REGION          669..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        305
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT   BINDING         261
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         305
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         422
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT   BINDING         481
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         482
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ   SEQUENCE   720 AA;  81901 MW;  E687A127C23E1B81 CRC64;
     MQTLKRLRLF LNTRLGFFTL LLFFFWLKTI TAYLVDFNLG VTGIYQYFVL LLNPIGTTML
     LLGLALYIKK PIISYLTMFL IYIANSALLF FNVIYYREFT DFMTINTMLG YSKVSEGISG
     SSFALMKPHD IFYVIDLALI ILLFITRYLK FNANPFKKIN AFAIMSFSIM LTLATLTLGE
     IDRPQLITRT FDRNYIVKYL GIDSYTVYDS FKTVKNNRVR DTAESYDLNK VLDFTKSHYA
     SPNPSMYGVA KGKNVIVIHL ESFQQFLINF KVNGKEVTPF LNSLYNGKQT YSFPNFFNQV
     GQGKTSDAEN LLETSIYGLA QGSVFTSLGS ENTFEAAPAI LNQTSGYSSA VFHGNTGSFW
     NRDTVYKSMG YQYFFDSSYY DNSAKNTLEY GLKDKLLFND SVKYLERLQQ PFYAKFITVS
     NHFPFDIDSQ NKDFEVPNTG DTSVNNYFQT AHYLDESVKE FFDYLQKSGL YNNSMVVLYG
     DHYGISNSRN VKLAKLLGKS SETWSSFDNT QMQRVPFMVH IPGINNGGVQ PEYGGEVDVL
     PTLLHLLGQD SSSYVQFGTD LFSKTHDQTV AFRNENFITP DYTVLDSTIY DNTTGKEVTH
     PSKSVQETIK KEQKKVSIEL NLSDTVNNQN LLRYYTPNNF KPVQPAEYNY KNQYDKLLKL
     QQELKNNSTS LYSEKGNKST TNLYKTDAPE LKPASESSSS DSKISSAATS AAHKSNSSSN
//
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