ID A0A0R1HS57_9LACO Unreviewed; 662 AA.
AC A0A0R1HS57;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Cell division protein FtsI {ECO:0000313|EMBL:KRK49247.1};
GN ORFNames=FC96_GL000169 {ECO:0000313|EMBL:KRK49247.1};
OS Secundilactobacillus kimchicus JCM 15530.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Secundilactobacillus.
OX NCBI_TaxID=1302272 {ECO:0000313|EMBL:KRK49247.1, ECO:0000313|Proteomes:UP000050911};
RN [1] {ECO:0000313|EMBL:KRK49247.1, ECO:0000313|Proteomes:UP000050911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 15530 {ECO:0000313|EMBL:KRK49247.1,
RC ECO:0000313|Proteomes:UP000050911};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRK49247.1}.
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DR EMBL; AZCX01000001; KRK49247.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R1HS57; -.
DR STRING; 1302272.FC96_GL000169; -.
DR PATRIC; fig|1302272.5.peg.166; -.
DR Proteomes; UP000050911; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KRK49247.1};
KW Cell division {ECO:0000313|EMBL:KRK49247.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000050911}.
FT DOMAIN 45..277
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 322..646
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 662 AA; 70637 MW; 4387069C697A7F30 CRC64;
MNFLFIIVGL LFAALVGQLA YLQIIYGARF QAEVNRTDNT VETNNVQRGM IFDSTGRVLV
GNRSHQAITY TKGVNVLSTD MYKTANKLGK YLNVSTVSLT KRNAADYYLT DVNRLKTVES
SVPNIKSFSV NDRYDKALDF VINHPSRYRL TAQQQNAAAI FAKMSGAYQL STTYIKDQGV
TNSELAEVGE HLGELPGVKI GTSWSRNYPY GSSIKSILGT VSSEKVGLPS DRVNQLLSQG
YSRNDSVGQS YLEEQYEPVL RGTKSQTEVD VSGTQITKEV QKYAGQKGDN LQLTINAGFQ
KRLQALVKSA EQGAGGNSTG TYAVVMNPNN GAVIGMAGVD RNPSSGKITD NALGTINNAI
TMGSVVKGAM VSGALMSGVI SPSNSTLTDS PINVGGMKKS SWFNHNGGSN IAVDASGALE
VSSNSYMMQL AMKEAGYNYV PGAALTMNPN IFNKLRGYFN QFGLGVKTGI DLPGETTGLQ
GPSGFSNIGK ALDLSFGNYD AYTTIQVAQY MSTIANGGYR IRPHLVSSIR GTSSSGGLGA
VKDSVTPDVM NKVGLTKAQL NVVKQGLYQV VHGSNQYKTG GELSSIKPEI SAKTGTAQTF
YKGGETVTLS LASYAPSKHP QVVVALAMPN LGVNAESNNM ALAKQIYAAY WKMVESSSTT
AE
//
