ID A0A0R1LR57_9LACO Unreviewed; 847 AA.
AC A0A0R1LR57;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=FD04_GL001267 {ECO:0000313|EMBL:KRK98286.1};
OS Secundilactobacillus odoratitofui DSM 19909 = JCM 15043.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Secundilactobacillus.
OX NCBI_TaxID=1423776 {ECO:0000313|EMBL:KRK98286.1, ECO:0000313|Proteomes:UP000051160};
RN [1] {ECO:0000313|EMBL:KRK98286.1, ECO:0000313|Proteomes:UP000051160}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19909 {ECO:0000313|EMBL:KRK98286.1,
RC ECO:0000313|Proteomes:UP000051160};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRK98286.1}.
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DR EMBL; AZEE01000028; KRK98286.1; -; Genomic_DNA.
DR RefSeq; WP_056948141.1; NZ_AZEE01000028.1.
DR AlphaFoldDB; A0A0R1LR57; -.
DR STRING; 1423776.FD04_GL001267; -.
DR PATRIC; fig|1423776.4.peg.1281; -.
DR OrthoDB; 9803432at2; -.
DR Proteomes; UP000051160; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Exonuclease {ECO:0000313|EMBL:KRK98286.1};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nuclease {ECO:0000313|EMBL:KRK98286.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}.
FT DOMAIN 161..251
FT /note="RecD helicase-like helix-hairpin-helix"
FT /evidence="ECO:0000259|Pfam:PF14490"
FT DOMAIN 593..666
FT /note="RecD-like DNA helicase SH3"
FT /evidence="ECO:0000259|Pfam:PF18335"
FT DOMAIN 683..730
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13538"
FT REGION 771..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 370..374
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 847 AA; 93282 MW; 563F8EC3DBD2F32F CRC64;
MASETIDLFD AQPQPQQPYL VGQVVATFFE SPDSFYKVLL VKVSATNLDW HGDEIVVTGN
FADVTEEMPY RFFGQLVDHP KYGQQFQAAN YQNEAPTTKE GIVAYLSGDD FPGLGKKTAE
KIVALLGLTA IDQINQDPSV LDPLGLKASV KQSLIDNLAS NNGVEQIIIG LNGYGFGSRM
ASAIFERYKE RTLQVIQENP YQLVEDINGV SFKRADQIAE QLGIEALSPQ RLQAGLLQAL
NELAMSEGNT YTTAEPLLKS TIHILQESRN VAVAPQAVAD QLLELGKAQK VVGEGNRIFL
KQLYDAEWQA AEHLNRLANS EQVKQFDDET LTKKMRIVER NLGITYDQSQ EDAILNAIQS
PLFLLTGGPG TGKTTIINGI VNLYAKLHDL SLDINQYKDK PFPILLAAPT GRAAKRMSET
TGLPASTIHR LLGLTGRESN DEAAAKDLEG SLLIIDEMSM VDIFLFRTLL RAIPDTMQIV
FVGDKDQLPS VGPGQVFYDL LRSHRVNAME LTTIYRQGND SSIIPLAHDI KTGKLPADFT
QNKPDRSFIQ CNAFQMPSVI EQIIGKAKAR GFSAEDVQVL APMYRGPAGI TRLNTIIQDI
MNPLTATHKK QVEFRDEKFR IGDKVLHLVN SPENNVFNGD IGEIVGITFA KDKGNSDKVD
KLTVAFDQTE VTYPRNEWDK LTLAYCTSIH KAQGSQFKMV ILPMVMQFSR MLQRNLLYTA
ITRAKSTLIL LGEQRAFQVS VERQSVNRQT ALVDRLTATI SEVAESNVLA SPDTSEATAK
DVTNLASSAT TPNEIDTPQK ATKTVEQPEI LNDGILTAEL ISSGQIDPMI GMGKVTPKSF
TISNSVV
//
