ID A0A0R1PAK5_9LACO Unreviewed; 707 AA.
AC A0A0R1PAK5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=NhaP-type Na H and K H antiporter {ECO:0000313|EMBL:KRL29289.1};
GN ORFNames=FD33_GL001023 {ECO:0000313|EMBL:KRL29289.1};
OS Companilactobacillus paralimentarius DSM 13238 = JCM 10415.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Companilactobacillus.
OX NCBI_TaxID=1122151 {ECO:0000313|EMBL:KRL29289.1, ECO:0000313|Proteomes:UP000051908};
RN [1] {ECO:0000313|EMBL:KRL29289.1, ECO:0000313|Proteomes:UP000051908}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13238 {ECO:0000313|EMBL:KRL29289.1,
RC ECO:0000313|Proteomes:UP000051908};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRL29289.1}.
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DR EMBL; AZES01000131; KRL29289.1; -; Genomic_DNA.
DR RefSeq; WP_025085863.1; NZ_BAMH01000068.1.
DR AlphaFoldDB; A0A0R1PAK5; -.
DR PATRIC; fig|1122151.5.peg.1061; -.
DR OrthoDB; 9809206at2; -.
DR Proteomes; UP000051908; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 83..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 215..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 239..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 276..297
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 390..413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 8..414
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 424..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 79409 MW; 0877FA34EB8B1D91 CRC64;
MEIIESIILI LSLLIIANIV SHYFVSIPPS LLQIAAGILA ALFMHVKIYV DTEWFLLAFI
APILFNDGNN FPKRELWKLK GPILGNAIIL VILSTVIGGV FVKWLIPQLP WATAFTLVAV
LSPTDPIAVE SIAKKAHIPD KLMHLINGES LINDASGLIC FKYGVAATVT GVFSLKSATI
DFFHISIIGA LVGAVMIWIF NGIRLYLINQ GVDDSILHAI IQIIIPFIIY YVAEDVFDVS
GVVAVVIAGI LNISSGRNIS NFTPEIRLVT SRTWDLVVYV LNGIVFVLLG IEIPFAMEEL
VHNDNINTFG ATLLAFIIWI MLVVIRFLWS YIYSTFSNNG DGKIVLWSKT RFDDCLMSGI
SGVRGAVTMV GALSIPMTIK GGAAFPSRTL LLFIASAVII FSLLGATLLI PILTKNSAPV
AYRGSTLTSE NEDDESDEDS DETPIELTEF EANRVILEKT VKKLRSEMDD GDTAVYSSVI
AEYLYDVRNL GIQSRNQVKT SQISKHRVRG KKDAELWDIS FNCELEAIDE LYDNHEISDE
SYDLAIKKIA RYKKEIVHRR SNQTVEFFYN YFRRTYLQIK HLIYRSVNSD DIQQINQDSI
KISIAGAKNA LKKLQELNQS DSDDIDDDLI YIFQRHYEDR LELLQGKYRG RSPQFNSERM
NLEIKALSYR RAFVQDMLEQ GKISKTTANE LRKNINYSEE VISIGVD
//
