GenomeNet

Database: UniProt
Entry: A0A0R1QA05_9LACO
LinkDB: A0A0R1QA05_9LACO
Original site: A0A0R1QA05_9LACO 
ID   A0A0R1QA05_9LACO        Unreviewed;      1174 AA.
AC   A0A0R1QA05;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE            Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE            EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN   Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN   ORFNames=FD01_GL002214 {ECO:0000313|EMBL:KRL41225.1};
OS   Lacticaseibacillus manihotivorans DSM 13343 = JCM 12514.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1423769 {ECO:0000313|EMBL:KRL41225.1, ECO:0000313|Proteomes:UP000051790};
RN   [1] {ECO:0000313|EMBL:KRL41225.1, ECO:0000313|Proteomes:UP000051790}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13343 {ECO:0000313|EMBL:KRL41225.1,
RC   ECO:0000313|Proteomes:UP000051790};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC       polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC       release of RNAP and its truncated transcript from the DNA, and
CC       recruitment of nucleotide excision repair machinery to the damaged
CC       site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC       RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRL41225.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AZEU01000253; KRL41225.1; -; Genomic_DNA.
DR   RefSeq; WP_056964751.1; NZ_AZEU01000253.1.
DR   AlphaFoldDB; A0A0R1QA05; -.
DR   PATRIC; fig|1423769.4.peg.2381; -.
DR   OrthoDB; 9804325at2; -.
DR   Proteomes; UP000051790; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR   CDD; cd17991; DEXHc_TRCF; 1.
DR   Gene3D; 2.40.10.170; -; 1.
DR   Gene3D; 3.40.50.11180; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR   Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR   HAMAP; MF_00969; TRCF; 1.
DR   InterPro; IPR003711; CarD-like/TRCF_RID.
DR   InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR004576; Mfd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047112; RecG/Mfd.
DR   InterPro; IPR037235; TRCF-like_C_D7.
DR   InterPro; IPR005118; TRCF_C.
DR   InterPro; IPR041471; UvrB_inter.
DR   NCBIfam; TIGR00580; mfd; 1.
DR   PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR   Pfam; PF02559; CarD_TRCF_RID; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF03461; TRCF; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM01058; CarD_TRCF; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00982; TRCF; 1.
DR   SUPFAM; SSF141259; CarD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR   SUPFAM; SSF143517; TRCF domain-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000051790}.
FT   DOMAIN          633..794
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          815..969
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1174 AA;  131113 MW;  F267D065BAA12D45 CRC64;
     MDLIDLFNQE PALQKLWPQL NAGRHLVTGL NGSAKTLMLA TALRQLGRQL VVIEDNRYHA
     EELVADLGDL VGEDKVWAFP VEDVLAAEVA VSSPDTKNTR INTLNWLQKG EAGIIVTSLA
     GLKRLLPPRA VWQQAEIHLD MDAQVDLPQL TQQLIDAGYT RDSLVGVPGQ FAIRGGIIDV
     YPLNADDPVR IELFDTDVDS IRRFDMRTQR SIRQLNDIDI PPATDLIASR DVLKAAGERL
     LEEAKAAKKV AKSKVNKEAL TNGIIATAEQ LAQGETVDQL ALYMPSLYPD AEQLCDYAQA
     DALVVFDDYT RLLDADVNLV EETTAWYGGL QSEGRLLPDQ PNATIQSFDH DDQHAHLYLS
     LFQKGMGNLR LTSLTNIVSR NIQQFFSQMP LLKTEADRWR KQGMTVVYLV PEQTRLEKLA
     GNLRDFEVDT VISPKADLLE KTQQLVAGNL QNGFELPDLK LVVVTAHELF NTKTHRKARH
     QTLANAERLR SYTELVPGDY VVHVNHGIGQ YTGMQTLVVD GVHKDYITIV YQKGDQLFIP
     VSQLNMVQKY VAADGKKPKI NKLGGAEWQK TKRKVAAKIE DIADDLIKLY AEREAEPGFA
     FAPDDDLQKQ FEGEFAYPET ADQLRSVKEI KQDMEKPRPM DRLLVGDVGF GKTEVALRAA
     FKAVENGKQV ALLVPTTILA QQHFDTMSDR FADFPINVAM LSRFRTPAQS KETLKGLASG
     EVDIVVGTHR LLSKDVHYKD LGLLIVDEEQ RFGVKHKEKL KELKANVDVL TLTATPIPRT
     LNMSMLGVRD LSVIETPPTN RYPIQTFVME QNGGTIRSAI ERELERGGQV FYLHNRVEDI
     EQTVAQIEQL VPNATVAYAH GQMTETQLEN VIYDFLHGAY DVLVTTTIIE TGVDMPNVNT
     LIIEHADRYG LSQLYQLRGR IGRSSRVAYA YFMYQPDKVL TEVAEKRLQA IRDFTELGAG
     FKIAMRDLSI RGAGNLLGSQ QHGFIDSVGY DLYTQMLNEA VAAKQGNAKP KHLDTEVDLD
     LEAYLPTDYV SDSRQKIELY KRLREANNDD QLNEIQDDLI DRFGDYPKPV ENLLAITHMK
     QFADAALVEK ITQNGQTLVL TMSPAASEKL AGVEIFKALK ATTLKARVAA DAAKMKVSLT
     VPKTMQPADW LNELIAFCQA MQAIVAPNTS PIEV
//
DBGET integrated database retrieval system