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Database: UniProt
Entry: A0A0R1RAZ7_9LACO
LinkDB: A0A0R1RAZ7_9LACO
Original site: A0A0R1RAZ7_9LACO 
ID   A0A0R1RAZ7_9LACO        Unreviewed;       336 AA.
AC   A0A0R1RAZ7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=Lipoate--protein ligase {ECO:0000256|SAAS:SAAS00603724};
DE            EC=6.3.1.20 {ECO:0000256|SAAS:SAAS00603724};
GN   ORFNames=FD35_GL000807 {ECO:0000313|EMBL:KRL53841.1};
OS   Lactobacillus rossiae DSM 15814.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1114972 {ECO:0000313|EMBL:KRL53841.1, ECO:0000313|Proteomes:UP000051999};
RN   [1] {ECO:0000313|EMBL:KRL53841.1, ECO:0000313|Proteomes:UP000051999}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15814 {ECO:0000313|EMBL:KRL53841.1,
RC   ECO:0000313|Proteomes:UP000051999};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O.,
RA   Ritari J., Douillard F.P., Paul Ross R., Yang R., Briner A.E.,
RA   Felis G.E., de Vos W.M., Barrangou R., Klaenhammer T.R.,
RA   Caufield P.W., Cui Y., Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through
RT   comparative genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-lipoate + a [lipoyl-carrier
CC       protein]-L-lysine = a [lipoyl-carrier protein]-N(6)-(lipoyl)lysine
CC       + AMP + diphosphate. {ECO:0000256|SAAS:SAAS00603726}.
CC   -!- PATHWAY: Protein modification; protein lipoylation via exogenous
CC       pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.
CC       {ECO:0000256|SAAS:SAAS00701662}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRL53841.1}.
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DR   EMBL; AZFF01000014; KRL53841.1; -; Genomic_DNA.
DR   RefSeq; WP_017261545.1; NZ_JH724990.1.
DR   EnsemblBacteria; KRL53841; KRL53841; FD35_GL000807.
DR   PATRIC; fig|1114972.6.peg.812; -.
DR   UniPathway; UPA00537; UER00595.
DR   Proteomes; UP000051999; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009249; P:protein lipoylation; IEA:InterPro.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR019491; Lipoate_protein_ligase_C.
DR   InterPro; IPR004562; LipoylTrfase_LipoateP_Ligase.
DR   PANTHER; PTHR12561; PTHR12561; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF10437; Lip_prot_lig_C; 1.
DR   TIGRFAMs; TIGR00545; lipoyltrans; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00428641};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051999};
KW   Ligase {ECO:0000256|SAAS:SAAS00603725, ECO:0000313|EMBL:KRL53841.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00026749};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051999}.
FT   DOMAIN       26    217       BPL/LPL catalytic. {ECO:0000259|PROSITE:
FT                                PS51733}.
SQ   SEQUENCE   336 AA;  38442 MW;  6C9E4E150BBF5DBC CRC64;
     MYYVSMKSHN IGENLATEQY LMNNKKFDEP LLLFYYEEPC IIVGRNQNTQ EEINQKYVQE
     HNIRVTRRLS GGGAVYQDLG NLCFSFVVDS NSEEFGDFKS FTKPIVDALH KMGATTAEVS
     GRNDILVDGK KFSGNAMYTR NGKTFSHGTL MLNVDLDVVT HALNVPEDKI ASKGIKSVRS
     RVTNLRPYLD KEYQDIDVPT FRDILLKELF NVDDLADIKD REVKVTDDDQ KEIDKLYEQY
     YNNWDWVYGK SPEFTVKKRQ HFDYGTIDAR LNVDDGKINN IKFYGDFFGP EDVSALADKL
     TGVKYDRDDL ASALADVDLA KYFVGISKEQ LVDLLA
//
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