ID   A0A0R1RLU7_9LACO        Unreviewed;       694 AA.
AC   A0A0R1RLU7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Topoisomerase IA {ECO:0000313|EMBL:KRL57756.1};
GN   ORFNames=FC70_GL000227 {ECO:0000313|EMBL:KRL57756.1};
OS   Paucilactobacillus oligofermentans DSM 15707 = LMG 22743.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Paucilactobacillus.
OX   NCBI_TaxID=1423778 {ECO:0000313|EMBL:KRL57756.1, ECO:0000313|Proteomes:UP000051697};
RN   [1] {ECO:0000313|EMBL:KRL57756.1, ECO:0000313|Proteomes:UP000051697}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15707 {ECO:0000313|EMBL:KRL57756.1,
RC   ECO:0000313|Proteomes:UP000051697};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRL57756.1}.
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DR   EMBL; AZFE01000003; KRL57756.1; -; Genomic_DNA.
DR   RefSeq; WP_057889185.1; NZ_LN898144.1.
DR   AlphaFoldDB; A0A0R1RLU7; -.
DR   STRING; 1423778.FC70_GL000227; -.
DR   KEGG; lol:LACOL_1467; -.
DR   PATRIC; fig|1423778.4.peg.245; -.
DR   OrthoDB; 9803554at2; -.
DR   Proteomes; UP000051697; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   Gene3D; 3.40.50.140; -; 1.
DR   Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR   Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR   Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR   InterPro; IPR000380; Topo_IA.
DR   InterPro; IPR013497; Topo_IA_cen.
DR   InterPro; IPR013824; Topo_IA_cen_sub1.
DR   InterPro; IPR013825; Topo_IA_cen_sub2.
DR   InterPro; IPR013826; Topo_IA_cen_sub3.
DR   InterPro; IPR023405; Topo_IA_core_domain.
DR   InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR   PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR   Pfam; PF01131; Topoisom_bac; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   SMART; SM00437; TOP1Ac; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KRL57756.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051697};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          3..142
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|SMART:SM00493"
FT   DOMAIN          286..529
FT                   /note="DNA topoisomerase type IA DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM00437"
FT   REGION          458..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   694 AA;  77811 MW;  796F0FFEFC43E442 CRC64;
     MVDLLILAEK ASAAKHMAKA FGGMTGTVAD KTYKIVHAHG HLMEFKEPEK MVTTEEDKQR
     YSSWSDMKTM PWNEADFSWA KTYAKSYNSY TKKSKSTRED ITAIKAEAAN AESILLATDN
     DPSGEGDLLG WEIVNAIKWK KKVYRIRFAD ETPKSLNQAL QQMVEITDQF KQGEYLKSDA
     RSKWDFLSMQ LTRISTYAAR QAGYRVKVIN QGRLKSVIVL KIWQQQQLID QYIKTPYFEA
     KFKDPAGHIF ARNLKDDQQK QAARFTDEKS GREDIAKYTK SPVANIKRVR KFQAPGSMID
     LAKLGSILAK QGFNSKEVLA TYQKMYEAEI VSYPRTEDKK ITQEQYNELL PVIDAIAAVV
     GANQQLLTHR VLRSKHHANE AAHGANRPGV KVPNSLSALT KYGPSAQAIY RTLALNYLAI
     LGEDYEFERV TAELEKYPEF KTGFNVPVKL NYKAIFDDTE GDDEPTEAKS DEVGPEAEPF
     VYQGANPKPT RPSADWIGKF LEKHNIGTGA TRLGVQAQLT SGKNAFILEK RGFYTLTQPG
     TIAAVLVRDS WIGSPSITKQ LFDHMDAVGK LNEVPSVVVN SATKVIEHDL PIILKNSQEL
     AQLVGSSQNV KSVKKFKAKP KTKGQYLDGQ EIEFSSTWGG HQFTADEIQK MLQGSIISFD
     ATSKYGKAYT ATGTLKQQTY KGKKFWGFKA NFGK
//