ID A0A0R1RMX3_9LACO Unreviewed; 296 AA.
AC A0A0R1RMX3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Aldo keto reductase {ECO:0000313|EMBL:KRL55429.1};
GN ORFNames=FC70_GL001026 {ECO:0000313|EMBL:KRL55429.1};
OS Paucilactobacillus oligofermentans DSM 15707 = LMG 22743.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Paucilactobacillus.
OX NCBI_TaxID=1423778 {ECO:0000313|EMBL:KRL55429.1, ECO:0000313|Proteomes:UP000051697};
RN [1] {ECO:0000313|EMBL:KRL55429.1, ECO:0000313|Proteomes:UP000051697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15707 {ECO:0000313|EMBL:KRL55429.1,
RC ECO:0000313|Proteomes:UP000051697};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRL55429.1}.
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DR EMBL; AZFE01000031; KRL55429.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R1RMX3; -.
DR STRING; 1423778.FC70_GL001026; -.
DR PATRIC; fig|1423778.4.peg.1059; -.
DR Proteomes; UP000051697; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000051697}.
FT DOMAIN 42..275
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 67
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 125
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 92
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 296 AA; 34025 MW; 3819EC7F3284DA79 CRC64;
MLQLKQLTKR RTTMTNISNN YLNLSDGNKM PQQGFGVYKI TDQAEFDQAI ESAWNHGYRL
FDTAQMYKNE QNLGDSLKKL NVPRDEMFIT TKISEANQGY DGSINSLKES LKKLQMDYVD
LLLIHWPINT DFFETWRAFE DIKKSGLAKS IGVSNYDMVH LQYLATQAHE MPVINQIEVS
PLMSQKPMLK FNAENNIITQ AWSPLGRGKV LNHPTILAVA KDTGKSTAQV ILRWHLQNGI
AIIPKSIHDE RIAQNADIYD FELSTLQMEQ MDSVNTNHRV SKEPELVYEF GEQYPY
//
