GenomeNet

Database: UniProt
Entry: A0A0R1RTF1_9LACO
LinkDB: A0A0R1RTF1_9LACO
Original site: A0A0R1RTF1_9LACO 
ID   A0A0R1RTF1_9LACO        Unreviewed;       348 AA.
AC   A0A0R1RTF1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   ORFNames=FD35_GL000132 {ECO:0000313|EMBL:KRL57125.1};
OS   Furfurilactobacillus rossiae DSM 15814.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Furfurilactobacillus.
OX   NCBI_TaxID=1114972 {ECO:0000313|EMBL:KRL57125.1, ECO:0000313|Proteomes:UP000051999};
RN   [1] {ECO:0000313|EMBL:KRL57125.1, ECO:0000313|Proteomes:UP000051999}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15814 {ECO:0000313|EMBL:KRL57125.1,
RC   ECO:0000313|Proteomes:UP000051999};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRL57125.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AZFF01000001; KRL57125.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R1RTF1; -.
DR   STRING; 1114972.FD35_GL000132; -.
DR   PATRIC; fig|1114972.6.peg.134; -.
DR   eggNOG; COG1420; Bacteria.
DR   Proteomes; UP000051999; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000051999};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          5..71
FT                   /note="Winged helix-turn-helix transcription repressor HrcA
FT                   DNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03444"
FT   DOMAIN          107..325
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   348 AA;  38603 MW;  54D2DC87DCECD5D4 CRC64;
     MIKTLTERQK VILQAIVREY TETGAAVGSK ALAARLPIHV SSATIRNEMA SLEEQGYVQK
     EHTSSGRIPS LAGYRYYVDH LVNNDAVAHA DIQLIQNELS GSFNKIDEII EESANLLSEL
     TSYTAFTLKP EQADARLSGF RLVPLGNRQV MAILVMDSGE VANQTFTIPR SMSSDQLETV
     VRLINDQLVG LPITEIVDKL RVEIPAKVGQ YMQTPEGFLQ IFGRVLDQAA TERFFVGGRL
     NLLNFSVNHN PQDLKSLYQL FDTSDDIASV LSPPDNKVQV KIGNEITNDL LKHYSLVTGT
     YDVGSHGRGM IAVLGPTRMP YSRMIGLVGA FRQELAAKLL DYYRNLDD
//
DBGET integrated database retrieval system