ID A0A0R1SHV1_9LACO Unreviewed; 663 AA.
AC A0A0R1SHV1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=NhaP family Na+ H+ and K+ H+ antiporter {ECO:0000313|EMBL:KRL69062.1};
GN ORFNames=FC85_GL002282 {ECO:0000313|EMBL:KRL69062.1};
OS Lentilactobacillus diolivorans DSM 14421.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lentilactobacillus.
OX NCBI_TaxID=1423739 {ECO:0000313|EMBL:KRL69062.1, ECO:0000313|Proteomes:UP000052013};
RN [1] {ECO:0000313|EMBL:KRL69062.1, ECO:0000313|Proteomes:UP000052013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14421 {ECO:0000313|EMBL:KRL69062.1,
RC ECO:0000313|Proteomes:UP000052013};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRL69062.1}.
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DR EMBL; AZEY01000020; KRL69062.1; -; Genomic_DNA.
DR RefSeq; WP_057863918.1; NZ_AZEY01000020.1.
DR AlphaFoldDB; A0A0R1SHV1; -.
DR STRING; 1423739.FC85_GL002282; -.
DR PATRIC; fig|1423739.3.peg.2373; -.
DR Proteomes; UP000052013; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052013};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..406
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 663 AA; 74394 MW; 76822FEDA5F1E6A4 CRC64;
MDEVLLLAII FAAVVLANIL ARHITKIPLP FFLIFLGILL AGLPVYNNFN LDPSTFALAV
IAPMLFNEAQ NSSRLWIGRS ITNILSLAVG LVIVSVLVVG FGLHLVYAIM PISLAFALLA
IVTPTDASAV NSIFESNPVT EEQAGILQHE SLFNDAAGIV IFDMSLTAFI SGTFSMEVAI
GTFLWEFLGG LLFGSLIGVL IVSARLILIR YNDDTPLIMV LIQLLSPFLV YLLAEKLALS
GILAVVAAGL VQGSEREKLR LTSSRMQLIT SNVWEIVSGM LSGMVFVLLG LSLPEVITAM
HQSPNPNFGI YKLIGIGLLI YFVKGVIRLV WSRYMIKRRV QTNREWRDSL VMAFSGANGT
ITLSLAFSIP TVVNGQPFEF RGPLIFLAAV VILISLIMPT IFVPLLLPSQ DAAQPRYRWV
RRMIQAAITD LVKEKEYPEE AQIVIDSLQQ QLVLDAAPNL KLRRQLMSES HQVERAAIQK
MYDEGKITKD EQFYYGKFLQ LNNFSADEKI WKNILLRIRF SLHIGTLYKD MSRAQDAFLT
APVVLEEVYW REQFQKHGED ILPIEQVGFD AVMAFLKTKD ADNGVESNMV KRFYRTRHRR
IHGKDVNADI VYQMFMRAFH SEYELIQDAL SSGKINSSLA EKLQQRISID EMTYLQNVEM
FSD
//
