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Database: UniProt
Entry: A0A0R1UBN4_9LACO
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ID   A0A0R1UBN4_9LACO        Unreviewed;       603 AA.
AC   A0A0R1UBN4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN   ORFNames=FC46_GL001652 {ECO:0000313|EMBL:KRL90807.1};
OS   Lactobacillus kalixensis DSM 16043.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1423763 {ECO:0000313|EMBL:KRL90807.1, ECO:0000313|Proteomes:UP000051036};
RN   [1] {ECO:0000313|EMBL:KRL90807.1, ECO:0000313|Proteomes:UP000051036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16043 {ECO:0000313|EMBL:KRL90807.1,
RC   ECO:0000313|Proteomes:UP000051036};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000256|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC       Rule:MF_00203}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRL90807.1}.
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DR   EMBL; AZFM01000006; KRL90807.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R1UBN4; -.
DR   STRING; 1423763.FC46_GL001652; -.
DR   PATRIC; fig|1423763.3.peg.1679; -.
DR   Proteomes; UP000051036; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   NCBIfam; TIGR00194; uvrC; 1.
DR   PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR   PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF14520; HHH_5; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR   SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00203}; Endonuclease {ECO:0000313|EMBL:KRL90807.1};
KW   Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW   Rule:MF_00203}; Hydrolase {ECO:0000313|EMBL:KRL90807.1};
KW   Nuclease {ECO:0000313|EMBL:KRL90807.1};
KW   SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT   DOMAIN          18..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000259|PROSITE:PS50164"
FT   DOMAIN          200..235
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   DOMAIN          251..476
FT                   /note="UvrC family homology region profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50165"
SQ   SEQUENCE   603 AA;  69842 MW;  FBD7E59117E68C03 CRC64;
     MIFLATELVE NKLKLLPEKP GCYLMKDING TVIYVGKSKN LKNRVRSYFK SKQVGRRAEL
     VKEIRDYDII TVSTDKEAFL LEITLIKKYQ PYYNVQLKQG TGYPYIEITN ERDPQTKLTS
     VIHKDKGYYF GPYPNVYAAQ ATLKFIQKVF PLRRCNGHQG RPCLYYHMGQ CLGACFKNVP
     QKEYDDQIKR IKRFLNGDIA SVKQDLIQRM EEASADLEFE RAAEIRDQLK YIEETVEKQK
     IISNDNTQRD IFNFYVDKSW LSVQIFFLRQ AKLLRRETKV FPLTEENEPE DEFTSFIVQF
     YGQRNRVLPK EILVPEGIDN EDLSEILHVP VRTPQRGQKK ALLEMAKENA KLKLDDKFRL
     LELGNRKTKG AQKEIFDALG LPYGHVIESF DHSHIQGADP VSALVVFKDG EPDKTSYRKY
     KLKGEVEHQN GGDELRNTRE VVRRRYGRLL REHKKMPDLI LMDGGQIQVE ACEDVLRNEL
     NLNIPVAGMV KDDKHRTNHL LFGDPINGEA FKLIPLDPKS QGFYLMTRIQ DEVHRFAITF
     HRRTHAKNAL SSRLDEIKGI GPKSRNKLLR EFGSLKKIKE ASIDDLRNAG LTLTQAQSVK
     LTL
//
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