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Database: UniProt
Entry: A0A0R1UUE4_9LACO
LinkDB: A0A0R1UUE4_9LACO
Original site: A0A0R1UUE4_9LACO 
ID   A0A0R1UUE4_9LACO        Unreviewed;       739 AA.
AC   A0A0R1UUE4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Alpha-galactosidase {ECO:0000256|ARBA:ARBA00012755, ECO:0000256|PIRNR:PIRNR005536};
DE            EC=3.2.1.22 {ECO:0000256|ARBA:ARBA00012755, ECO:0000256|PIRNR:PIRNR005536};
GN   ORFNames=FC21_GL001139 {ECO:0000313|EMBL:KRL95091.1};
OS   Limosilactobacillus equigenerosi DSM 18793 = JCM 14505.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=1423742 {ECO:0000313|EMBL:KRL95091.1, ECO:0000313|Proteomes:UP000051084};
RN   [1] {ECO:0000313|EMBL:KRL95091.1, ECO:0000313|Proteomes:UP000051084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18793 {ECO:0000313|EMBL:KRL95091.1,
RC   ECO:0000313|Proteomes:UP000051084};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC         residues in alpha-D-galactosides, including galactose
CC         oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC         Evidence={ECO:0000256|ARBA:ARBA00001255,
CC         ECO:0000256|PIRNR:PIRNR005536};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 36 family.
CC       {ECO:0000256|ARBA:ARBA00006202}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRL95091.1}.
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DR   EMBL; AZGC01000026; KRL95091.1; -; Genomic_DNA.
DR   RefSeq; WP_054652273.1; NZ_BBAS01000001.1.
DR   AlphaFoldDB; A0A0R1UUE4; -.
DR   STRING; 417373.GCA_001570685_00108; -.
DR   PATRIC; fig|1423742.4.peg.1182; -.
DR   OrthoDB; 9758822at2; -.
DR   Proteomes; UP000051084; Unassembled WGS sequence.
DR   GO; GO:0004557; F:alpha-galactosidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   CDD; cd14791; GH36; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 2.70.98.60; alpha-galactosidase from lactobacil brevis; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR038417; Alpga-gal_N_sf.
DR   InterPro; IPR000111; Glyco_hydro_27/36_CS.
DR   InterPro; IPR002252; Glyco_hydro_36.
DR   InterPro; IPR031705; Glyco_hydro_36_C.
DR   InterPro; IPR031704; Glyco_hydro_36_N.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR43053:SF3; ALPHA-GALACTOSIDASE-RELATED; 1.
DR   PANTHER; PTHR43053; GLYCOSIDASE FAMILY 31; 1.
DR   Pfam; PF16874; Glyco_hydro_36C; 1.
DR   Pfam; PF16875; Glyco_hydro_36N; 1.
DR   Pfam; PF02065; Melibiase; 1.
DR   PIRSF; PIRSF005536; Agal; 1.
DR   PRINTS; PR00743; GLHYDRLASE36.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   PROSITE; PS00512; ALPHA_GALACTOSIDASE; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR005536};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR005536};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051084}.
FT   DOMAIN          32..284
FT                   /note="Glycosyl hydrolase family 36 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16875"
FT   DOMAIN          651..734
FT                   /note="Glycosyl hydrolase family 36 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16874"
FT   ACT_SITE        478
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-1"
FT   ACT_SITE        548
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-1"
FT   BINDING         199
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         366..367
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         443
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         476..480
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         526
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         548
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
SQ   SEQUENCE   739 AA;  84618 MW;  65944B2CB77B5DA6 CRC64;
     MSIHYNEQTK VFHLQTDHTS YIFQILPTGV AGQVYYGPQI PVKAEYQNLM TREEHDCTNT
     YTDEQTDLQY ELLKQEYASY GSGDYRYPAV SVTNPTGDRI SEFKFTNAEI VDGKDRLAEL
     PSTFDDDHHD AQTLHVHFVD AVNQLEMVLN YTVFATEDVI ARSTTFINHG EPLKLNRALS
     LQLDLPDFNY DLIQFDGSWA RERHLHRTPL RYGMQSNSSL RFTSGHHSNP FFMLARPETN
     ELTGSAYGFN LIYSGNFIDS VEVDQFDVAR VLTGINPAEF SWELTSDATF QTPEAIMTYT
     DAGLNTLSQN LADFYNHHLL PSRFVKQERP TLVNNWEATF MDFTEDKLMP IVNKAHDLGI
     EMFVLDDGWF GHRDNDQSSL GDWFVDHKKF VNGVGGFAHR VHQLGMKFGL WFEPEMVSED
     SELFKAHPEW RIGAPHRHHT PARHQFVLDY SNPAVVDFIY DEMAKVITDT KLDYVKWDMN
     RSITEAFSTN LPADRQTEFG HRYILGVYRL YDRLTTAFPN VLFESCASGG GRFDLGMMYY
     APQAWASDNT DAVERLSVQT GSSYGYSQNM WGAHVSAVPN DQNGRLTSLD FRAKVAYFGA
     FGYELDLNEL SNAEQAQVKD QVAFYKQYRS LFQFGKFYRL PQRLQNPANV TAWAVVNDDQ
     TQAIATYFQV LNPANPAYVR FYLAGLDPQK HYRVNDGDEI FSGQELMTAG YFLPRIMPRV
     AHKDPADFKA TMLIIKAVD
//
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