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Database: UniProt
Entry: A0A0R1VM74_9LACO
LinkDB: A0A0R1VM74_9LACO
Original site: A0A0R1VM74_9LACO 
ID   A0A0R1VM74_9LACO        Unreviewed;       710 AA.
AC   A0A0R1VM74;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   10-APR-2019, entry version 14.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   ORFNames=FC89_GL002331 {ECO:0000313|EMBL:KRM04388.1};
OS   Lactobacillus ghanensis DSM 18630.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1423750 {ECO:0000313|EMBL:KRM04388.1, ECO:0000313|Proteomes:UP000051451};
RN   [1] {ECO:0000313|EMBL:KRM04388.1, ECO:0000313|Proteomes:UP000051451}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18630 {ECO:0000313|EMBL:KRM04388.1,
RC   ECO:0000313|Proteomes:UP000051451};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O.,
RA   Ritari J., Douillard F.P., Paul Ross R., Yang R., Briner A.E.,
RA   Felis G.E., de Vos W.M., Barrangou R., Klaenhammer T.R.,
RA   Caufield P.W., Cui Y., Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through
RT   comparative genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRM04388.1}.
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DR   EMBL; AZGB01000029; KRM04388.1; -; Genomic_DNA.
DR   RefSeq; WP_057872682.1; NZ_AZGB01000029.1.
DR   EnsemblBacteria; KRM04388; KRM04388; FC89_GL002331.
DR   PATRIC; fig|1423750.3.peg.2374; -.
DR   OrthoDB; 304844at2; -.
DR   Proteomes; UP000051451; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000051451};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051451};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    280    298       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    422    446       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    452    472       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    515    536       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    611    631       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    643    662       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    668    689       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN        1    162       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
SQ   SEQUENCE   710 AA;  79457 MW;  975205401299B125 CRC64;
     MKMIALAGNP NSGKTTLFNW LTGSNQSVGN WPGVTVEKKQ GLLRSNKQFM IQDLPGIYSL
     SPYTAEEVVS RKYLVEQTPD AVVDIVDATN IERNLYLTLQ LMETGRPLVV ALNMIDMLKK
     QQRKVNLKKL SYLLGVPVVG ISALKRKNLP QLEQAMIAET QRKTTYSFPK YDDRLESALT
     MISQQITGIV STERLRWYAI KLFERDEQVN QELNLTAEKS KEIEKIIITA EKVFQDTSDS
     IIVNARYDLI SQFVKMSVVD ETDFVVSMSD RVDRIITNRW LALPIFFFVM WLVYYLSIQT
     IGTMGTDWVN DVLFGKIIPD AVQGWLTQWH VAAWMQGLVL NGIINGLGSV LGFVPQIMML
     FLCLGILEDC GYMARIAFVM DRIFHRFNLS GKSFIPMLIS TGCGVPGIMS TRTIENEKDR
     KMTIMLTTFM PCSAKLTVIA LISGTFFPHQ SWVAPSAYFL GMLAVVGSGI FLKKTRLFAG
     PPQPFVMELP AYHFPKPGNV LRQVISRAES FIKKAGTIIF SSCVLIWFFS SFTFTLKMTD
     QNHSMLRYIG EVVAPIFAPL GFGDWHTTVA VIAGLIAKEN CVGTLRITFG SSTASAFSAA
     LRQAYPAIAG YSFLAFNLLC APCFAAIGTM YKEFGNTKWT LRALGYQTAL AYLTAMLIYQ
     SVQMVTTWSF ASVVLTATAV LIILYCLFFK RNASDDLYQV KNEIGEGALK
//
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