ID A0A0R1WM64_9LACO Unreviewed; 643 AA.
AC A0A0R1WM64;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Carbamoyl phosphate synthase large subunit {ECO:0000313|EMBL:KRM19002.1};
GN ORFNames=FC40_GL000791 {ECO:0000313|EMBL:KRM19002.1};
OS Ligilactobacillus hayakitensis DSM 18933 = JCM 14209.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1423755 {ECO:0000313|EMBL:KRM19002.1, ECO:0000313|Proteomes:UP000051054};
RN [1] {ECO:0000313|EMBL:KRM19002.1, ECO:0000313|Proteomes:UP000051054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18933 {ECO:0000313|EMBL:KRM19002.1,
RC ECO:0000313|Proteomes:UP000051054};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the CarB family.
CC {ECO:0000256|ARBA:ARBA00009799}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRM19002.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZGD01000090; KRM19002.1; -; Genomic_DNA.
DR RefSeq; WP_025022026.1; NZ_BAML01000005.1.
DR AlphaFoldDB; A0A0R1WM64; -.
DR STRING; 1423755.FC40_GL000791; -.
DR PATRIC; fig|1423755.3.peg.845; -.
DR eggNOG; COG0458; Bacteria.
DR OrthoDB; 9804197at2; -.
DR Proteomes; UP000051054; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.20; -; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 1.10.1030.10; Carbamoyl-phosphate synthetase, large subunit oligomerisation domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005480; CarbamoylP_synth_lsu_oligo.
DR InterPro; IPR036897; CarbamoylP_synth_lsu_oligo_sf.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR PANTHER; PTHR11405:SF5; CAD PROTEIN; 1.
DR PANTHER; PTHR11405; CARBAMOYLTRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR Pfam; PF02787; CPSase_L_D3; 1.
DR SMART; SM01096; CPSase_L_D3; 1.
DR SUPFAM; SSF48108; Carbamoyl phosphate synthetase, large subunit connection domain; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 2.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000051054};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 122..316
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 643 AA; 72068 MW; 81ADFB97CDFE3BCB CRC64;
MQKIKGTKRV IVLGALNSGA INAVELLKEA GLKPILVAPK IDGYKIEGIT DEWFTVEVNA
ENLYEIIRQT NPGAILPTFG GQMAINACME LERSGLFNAL GIEILGTNLN SLKKIFDREL
FSEALREKGI STPKSKTINT ISDAEKFASE YGYPVIVRAA ATTMKPGGDL CNNFKELQKN
FKNAIEQSPV KNCLIEASVT GYKELEFEVM RDELDNCILI GSFEDFDAVG IHAADSIVVS
PIKTLNNYQF NMLRTVSLKL ARMFRIVGSC NIRIAFDSST NKYYILEMNA SYNRSSALVA
TVTTYPVAEV ITKVSFGENL IDIKRVGSKI LTAANEPILD YVAIKIPNWS DKINRTRLGT
RKKATSQLVA FGRTLESALM KAIRSIPIRE IDGKFMSNMK VDDFELENNL VHAQSDRIFY
IAEAFRRDYT IREVSRLSKI DPQFLVVINN LVNYFNKGNM YNANLDNIKS AKMMGYSDFW
MSKNWNMQES ELYNDRTKAG ISVKYNRMDS SAGTLDSTAP FFYGTYEELD ELVESENQLD
VLIVDGVSKL SSENFARNQT LSILAKSGLK IGLISNSPDT LSMAVSMPIT IFVEPVTFES
IKNIYERCNP KTICLKDPKG ISDKLIDQLY DSDFKVVTWN ELN
//
