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Database: UniProt
Entry: A0A0R1XM23_9LACO
LinkDB: A0A0R1XM23_9LACO
Original site: A0A0R1XM23_9LACO 
ID   A0A0R1XM23_9LACO        Unreviewed;       283 AA.
AC   A0A0R1XM23;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   11-DEC-2019, entry version 18.
DE   RecName: Full=2-dehydro-3-deoxyphosphooctonate aldolase {ECO:0000256|SAAS:SAAS00700405};
DE            EC=2.5.1.55 {ECO:0000256|SAAS:SAAS00700404};
GN   ORFNames=FC91_GL000527 {ECO:0000313|EMBL:KRM29508.1};
OS   Lactobacillus harbinensis DSM 16991.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1122147 {ECO:0000313|EMBL:KRM29508.1, ECO:0000313|Proteomes:UP000050949};
RN   [1] {ECO:0000313|EMBL:KRM29508.1, ECO:0000313|Proteomes:UP000050949}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16991 {ECO:0000313|EMBL:KRM29508.1,
RC   ECO:0000313|Proteomes:UP000050949};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-
CC         alpha-D-manno-2-octulosonate-8-phosphate + phosphate;
CC         Xref=Rhea:RHEA:14053, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57693, ChEBI:CHEBI:58702, ChEBI:CHEBI:85985; EC=2.5.1.55;
CC         Evidence={ECO:0000256|SAAS:SAAS01123735};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis. {ECO:0000256|SAAS:SAAS00700395}.
CC   -!- PATHWAY: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate
CC       biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate:
CC       step 2/3. {ECO:0000256|SAAS:SAAS00700401}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00700398}.
CC   -!- SIMILARITY: Belongs to the KdsA family.
CC       {ECO:0000256|SAAS:SAAS00700400}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRM29508.1}.
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DR   EMBL; AZFW01000013; KRM29508.1; -; Genomic_DNA.
DR   RefSeq; WP_027828899.1; NZ_AZFW01000013.1.
DR   STRING; 1122147.AUEH01000032_gene2479; -.
DR   EnsemblBacteria; KRM29508; KRM29508; FC91_GL000527.
DR   PATRIC; fig|1122147.4.peg.547; -.
DR   OrthoDB; 687380at2; -.
DR   UniPathway; UPA00030; -.
DR   UniPathway; UPA00357; UER00474.
DR   Proteomes; UP000050949; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008676; F:3-deoxy-8-phosphooctulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006269; KDO8P_synthase.
DR   PANTHER; PTHR21057; PTHR21057; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   TIGRFAMs; TIGR01362; KDO8P_synth; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00700397};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|SAAS:SAAS00700406};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050949};
KW   Transferase {ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN          15..255
FT                   /note="DAHP_synth_1"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
SQ   SEQUENCE   283 AA;  30892 MW;  655428D7B8A4A0DF CRC64;
     MATIATVFKD YGFHNDQLTL LAGPCAIESY DTCAQVAEIL GSLADELHIN YVFKSSFDKA
     NRSSGEADRG AGLEAGLKVL RRIKETYHVP IVTDVHESYQ CAPVAEVADV LQIPAFLSRQ
     TDLLVAAAKT GRVVNVKKGQ FMAPEDMGSV VDKLDPYTEK ILLTERGVSF GYHRLVVDMP
     GLITMRQFEY PVIFDATHSV QLPGGYGDHS GGQRDFAFPL MRAALTVGVD GIFAEVHPDP
     PSAISDADNQ LYLAKAAPIF REANTLFHEY QAAQKGRVQD GLL
//
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