ID A0A0R1ZN20_9LACO Unreviewed; 683 AA.
AC A0A0R1ZN20;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Cell division protein penicillin-binding protein 2 {ECO:0000313|EMBL:KRM56382.1};
GN ORFNames=FC18_GL000065 {ECO:0000313|EMBL:KRM56382.1};
OS Lacticaseibacillus sharpeae JCM 1186 = DSM 20505.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=1291052 {ECO:0000313|EMBL:KRM56382.1, ECO:0000313|Proteomes:UP000051679};
RN [1] {ECO:0000313|EMBL:KRM56382.1, ECO:0000313|Proteomes:UP000051679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20505 {ECO:0000313|EMBL:KRM56382.1,
RC ECO:0000313|Proteomes:UP000051679};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRM56382.1}.
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DR EMBL; AYYO01000005; KRM56382.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R1ZN20; -.
DR STRING; 1291052.FC18_GL000065; -.
DR PATRIC; fig|1291052.5.peg.67; -.
DR Proteomes; UP000051679; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KRM56382.1};
KW Cell division {ECO:0000313|EMBL:KRM56382.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000051679}.
FT DOMAIN 40..273
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 321..653
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 683 AA; 74188 MW; 5A74837EF559886B CRC64;
MAFLLFAGLV TQLAYLQISN GESFAAEVNR TGTTTVAGSV PRGEIYDAKG RIMVDNKAEA
AITYTKNVST PAEQMYTVAN RLANYVTVDA SSLRERDIQD YWLANPKNTK RVNKQLTKKQ
RKFKDNKLYK VQLKVAKTIK ISLTPAQKQA AAIYKIMNGA TQLSTVNIKD QKVTQKEIAV
VSEHLTSLPG VNLGTNWERE YPNGKSMNTV IGRVSSEKSG LPSESLMSYL ELGYARNDRV
GTSYLEKQYE TALRGSKSQT EVTLSSTNQI AKQVEKYNGK KGSNITLTID SKFQAKVESI
VKTQFNKALS NGNAALSDGA YAVVMNPNTG AVLSMVGFKH NFKTGKLDED SLGVINRSFV
MGSAVKPGMV LGALQDGVIT RTNNTQSEDP IYLKGTKVKS SDYPVGTYSS MTAQHAIEVS
SNIYMMRLVM KEAGVSGNDY IPKQRMRMNS DVFEKVRGYF NQFGLGLKTG IDMPGEVAPT
AGKKLNEYGV LNTGAALSIG FGNYDPYTLI EMGQYVSTIA NGGYRMQPYL VQSISQSNSD
GSTQVESTTE PNVLSKIGNS NADVNFVKQG MWLVGHGTDA WATAKVLGNL NPGVAAKTGT
AQSVAHVNPE DTSSAPVDTL NISLVAMAPA KNPQITVAVV MPNVSLSSHG YTKDMTHDII
QAYYDMYHVK KVSGYSSTQQ TMP
//
