ID A0A0R2A032_9LACO Unreviewed; 720 AA.
AC A0A0R2A032;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Cell division protein FtsI {ECO:0000313|EMBL:KRM56604.1};
GN ORFNames=FC18_GL002090 {ECO:0000313|EMBL:KRM56604.1};
OS Lacticaseibacillus sharpeae JCM 1186 = DSM 20505.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=1291052 {ECO:0000313|EMBL:KRM56604.1, ECO:0000313|Proteomes:UP000051679};
RN [1] {ECO:0000313|EMBL:KRM56604.1, ECO:0000313|Proteomes:UP000051679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20505 {ECO:0000313|EMBL:KRM56604.1,
RC ECO:0000313|Proteomes:UP000051679};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRM56604.1}.
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DR EMBL; AYYO01000003; KRM56604.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2A032; -.
DR STRING; 1291052.FC18_GL002090; -.
DR PATRIC; fig|1291052.5.peg.2151; -.
DR Proteomes; UP000051679; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR Gene3D; 2.20.70.70; -; 1.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR PROSITE; PS51178; PASTA; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KRM56604.1};
KW Cell division {ECO:0000313|EMBL:KRM56604.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000051679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 603..663
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 664..719
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
SQ SEQUENCE 720 AA; 76752 MW; 7801FD318A2FF5A2 CRC64;
MSKRKGRMSE KQMLEHLRRN RQWFGFILLS LTVLALVLIG VKYALIIHGQ ADEHNLTKSR
LSQVTRTKTV VAKRGEIVDV DGNAIASTGN TYTVYAIIKH QYKGDTSKIV KDKAKTAKLL
ANHLPVSEAE ILKRLNPANG HTTQVEFGGE GSGLSLATKQ AIEKENLAGI HFTTTPARLY
PNGIFASHEI GRTTATTSKN GLTTLAGTMG LEKSFNKLLT GTNGEKRMQT DRFGYTVAGT
AKTLKKAQNG GTVYTTINSN LQNYLESLMT SVQEKYSPTA MTATLMNAKT GAILATSQRP
TYEPTTGSGL ANAWRSMLVQ DVYEPGSVMK IMTLAAAINS GNYHPNEYYK SGQIKVDGAT
LSDWNKAGWG MIPLSQAFTR SSNVGMVKIE QAMGAKTWLS YLKKFGFGSK TGMPLPSESA
GSIAYSSTPD QASTAFGQAI NVTVVQMLRA MSAVADGGQM VEPRIVSKTE TASGKVTKYG
TKKLAKVISA DTAAQVREAM VKVVKDENGT GGSYAIKGMD VGVKTGTAQI SGAHGYLAGS
QNYLHSVAAM VPSKNPKYLV YITLKQPKIP AGTVSANDVI ATIFKPLIKR AIALESNSGS
EAGSAMTKIG NLDGQKLTTV RSDLQKQGFQ VAVIGTGNEV VQQLPVANQE AMNGSRVILM
TNGAMTMPSV SGWGKSDVLK LAQITGVKFK LKGEGYASAQ SLKAGSLITG DTVTVTFTSK
//
