ID A0A0R2A2E9_9LACO Unreviewed; 590 AA.
AC A0A0R2A2E9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Pyruvate oxidase {ECO:0000313|EMBL:KRM61120.1};
GN ORFNames=FC26_GL002338 {ECO:0000313|EMBL:KRM61120.1};
OS Paucilactobacillus vaccinostercus DSM 20634.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Paucilactobacillus.
OX NCBI_TaxID=1423813 {ECO:0000313|EMBL:KRM61120.1, ECO:0000313|Proteomes:UP000051733};
RN [1] {ECO:0000313|EMBL:KRM61120.1, ECO:0000313|Proteomes:UP000051733}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20634 {ECO:0000313|EMBL:KRM61120.1,
RC ECO:0000313|Proteomes:UP000051733};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRM61120.1}.
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DR EMBL; AYYY01000043; KRM61120.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2A2E9; -.
DR STRING; 1423813.FC26_GL002338; -.
DR PATRIC; fig|1423813.3.peg.2385; -.
DR Proteomes; UP000051733; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0047112; F:pyruvate oxidase activity; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 1.10.10.940; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR014092; Pyruvate_oxidase.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR NCBIfam; TIGR02720; pyruv_oxi_spxB; 1.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Pyruvate {ECO:0000313|EMBL:KRM61120.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051733};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 15..129
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 205..333
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 394..540
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 590 AA; 64011 MW; 5F83512CE12795D2 CRC64;
MIVFLEEDVK MSKINAADAM IKVLEDWHVD HLFGLPGGSF DSTMNALHNR KSTMKYIQVR
HEETGAIAAA GEAKLTGKIG VTFGSAGPGA VHLLNGLYDA KHDHAPVLAL VAQVPTSAMN
TDFFQELNEN PIFADVSVYN RTVMTAEQLP AVVDQAIRQA YEHSGVAVVT IPKDLGWAEI
EDNYVSTADN YVVTDNYPLP DQTAVDKAVE ILTNAKRPLI YFGLGAKKAA KELKQLSDQL
KIPLMSSALA KGVITDADEA YMGSAGRVAT KPGVDAASNA DAILFVGSNF PFASFFFNPA
AKFIQVDVKP TNIGKRHHVD VGLLADAKTA LQAFIDRSSA VESRAYYDAL VADKKNWLEW
LKKFVNEDQT PLRVDTVFEQ INQIAKDDAV FALDVGNVTI DGVRLLKMKP TQKITTSGWY
ATMGYALPTA IAAQASYPDR QVFSISGDGG FTMVMHDILT QVKYRQPIIN VVLTNESLGF
IEAEQDDTGQ PHSGVDLIDA NFGDAATALG AKGYEVKTLA ELKAAFKDAQ TVNGPTVIDV
KISDDRPLPV EQLVLEADGN HTQADVDAFV KQYHADGLIP FSQLLNQFNA
//
