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Database: UniProt
Entry: A0A0R2AXD5_9LACO
LinkDB: A0A0R2AXD5_9LACO
Original site: A0A0R2AXD5_9LACO 
ID   A0A0R2AXD5_9LACO        Unreviewed;       733 AA.
AC   A0A0R2AXD5;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Alpha-galactosidase {ECO:0000256|ARBA:ARBA00012755, ECO:0000256|PIRNR:PIRNR005536};
DE            EC=3.2.1.22 {ECO:0000256|ARBA:ARBA00012755, ECO:0000256|PIRNR:PIRNR005536};
GN   ORFNames=FC34_GL001312 {ECO:0000313|EMBL:KRM71655.1};
OS   Lacticaseibacillus brantae DSM 23927.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1423727 {ECO:0000313|EMBL:KRM71655.1, ECO:0000313|Proteomes:UP000051672};
RN   [1] {ECO:0000313|EMBL:KRM71655.1, ECO:0000313|Proteomes:UP000051672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23927 {ECO:0000313|EMBL:KRM71655.1,
RC   ECO:0000313|Proteomes:UP000051672};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC         residues in alpha-D-galactosides, including galactose
CC         oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC         Evidence={ECO:0000256|ARBA:ARBA00001255,
CC         ECO:0000256|PIRNR:PIRNR005536};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 36 family.
CC       {ECO:0000256|ARBA:ARBA00006202}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRM71655.1}.
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DR   EMBL; AYZQ01000003; KRM71655.1; -; Genomic_DNA.
DR   RefSeq; WP_057894606.1; NZ_AYZQ01000003.1.
DR   AlphaFoldDB; A0A0R2AXD5; -.
DR   STRING; 1423727.FC34_GL001312; -.
DR   PATRIC; fig|1423727.3.peg.1332; -.
DR   OrthoDB; 9758822at2; -.
DR   Proteomes; UP000051672; Unassembled WGS sequence.
DR   GO; GO:0004557; F:alpha-galactosidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   CDD; cd14791; GH36; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 2.70.98.60; alpha-galactosidase from lactobacil brevis; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR038417; Alpga-gal_N_sf.
DR   InterPro; IPR000111; Glyco_hydro_27/36_CS.
DR   InterPro; IPR002252; Glyco_hydro_36.
DR   InterPro; IPR031705; Glyco_hydro_36_C.
DR   InterPro; IPR031704; Glyco_hydro_36_N.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR43053:SF3; ALPHA-GALACTOSIDASE-RELATED; 1.
DR   PANTHER; PTHR43053; GLYCOSIDASE FAMILY 31; 1.
DR   Pfam; PF16874; Glyco_hydro_36C; 1.
DR   Pfam; PF16875; Glyco_hydro_36N; 1.
DR   Pfam; PF02065; Melibiase; 1.
DR   PIRSF; PIRSF005536; Agal; 1.
DR   PRINTS; PR00743; GLHYDRLASE36.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   PROSITE; PS00512; ALPHA_GALACTOSIDASE; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR005536};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR005536};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051672}.
FT   DOMAIN          30..283
FT                   /note="Glycosyl hydrolase family 36 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16875"
FT   DOMAIN          650..727
FT                   /note="Glycosyl hydrolase family 36 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16874"
FT   ACT_SITE        477
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-1"
FT   ACT_SITE        547
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-1"
FT   BINDING         198
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         365..366
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         442
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         475..479
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         525
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
FT   BINDING         547
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005536-2"
SQ   SEQUENCE   733 AA;  82741 MW;  77C12519348C10AD CRC64;
     MITFDKTKQQ FHLSNGLISY VMRIEALSIL GQVYFGKAIT DPQGLRRYPL IDRSFSPNFP
     ETHSRDYSLD TQPLEYPSGL GDFREPAIDV VQANGAHYLD LRYVDYAILA GKPELVGLPA
     TFSTDQHSAE TLRVHLRDAN FNVDVYLNYA IFAGLPVVAR SAEIVNNGDE PIHLDRAFSA
     SLDFPLGDWE ALSLAGSWSN ERQIVRQPLT HGNYEVSTKR GTSSHQENPF LALLHPTTTE
     DQGEVYGFSL VYSGNHRLQA EVDQYGCIRV QAGINDYRFD WELSPKAHFQ TPEVVMAYSD
     HGLNAMSQAY HQLYIDNLMT SRFKREVRPI LVNNWEATFF DFTTESLKPI INQAAKLGIE
     MFVLDDGWFG HRDNDKSSLG DWFEFKGKIA GGLGEFAQYV HQKGLKFGLW FEPEMVSADS
     ELYRRHPDWA FAVPNTTPLL GRDQYVLDFS RSEVRDYIYQ EITGVLDSVD INYIKWDMNR
     SLTDVFSLAL PKDRQGEVYH RYILGLYELL DRLTTRYPDI LFESCSGGGG RFDPGMLYYM
     PQTWTSDNTD AVSRLNIQYG TSLVYPPVAM GNHVSAVPNS QTGRTTSLDT RAAVAMAGNF
     GYELDLNALT TEAQAAVTKQ VAFYKQNREL LQFGTFYRLT SPFDAHSNGA SWGMVSKDQQ
     DAIFFVYTLG AAPNPSLKVI KFAGLIPTQH YQVSGFKGAF TGSELMSVGF YLDVNAYRGD
     YNSRIYRVTA VNE
//
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