ID   A0A0R2BK61_9LACO        Unreviewed;       770 AA.
AC   A0A0R2BK61;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=DNA helicase {ECO:0000313|EMBL:KRM79896.1};
GN   ORFNames=FC84_GL000595 {ECO:0000313|EMBL:KRM79896.1};
OS   Lapidilactobacillus dextrinicus DSM 20335.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lapidilactobacillus.
OX   NCBI_TaxID=1423738 {ECO:0000313|EMBL:KRM79896.1, ECO:0000313|Proteomes:UP000051813};
RN   [1] {ECO:0000313|EMBL:KRM79896.1, ECO:0000313|Proteomes:UP000051813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20335 {ECO:0000313|EMBL:KRM79896.1,
RC   ECO:0000313|Proteomes:UP000051813};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRM79896.1}.
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DR   EMBL; AYYK01000001; KRM79896.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R2BK61; -.
DR   STRING; 1423738.FC84_GL000595; -.
DR   PATRIC; fig|1423738.3.peg.604; -.
DR   Proteomes; UP000051813; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR048228; HelD_bacillota.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   NCBIfam; NF041464; HelD_BACSU; 1.
DR   PANTHER; PTHR11070:SF17; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000051813}.
FT   DOMAIN          215..607
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         236..243
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   770 AA;  89027 MW;  3121435222BD287A CRC64;
     MADSHEPIRN TQAAEQQYLD DVVQKIGQAQ KKAQVSIDQA ANDEKSINKH FGEEVKLNFG
     DYSTNLETAL SIHQQQQMLA ERENSWQQST RRLNTLNRLI DNPYFARLDF HEHGEPKRET
     IYIGLSSFTD KNDKFLIYDW RAPISSIYYD GKLGEVTYQT PDGEQSVNIT LKRQFLIKKG
     QIESMFDTSE TIGDQMLLEV LGEKSSTQMK SIVTTIQKEQ NKIIRNTKAD LLFVQGAAGS
     GKTSAILQRV AYLLYRYRGN LTSSQVVMFS PNQLFNDYIE NVLPELGEQN MVQMTYQQYV
     GRRLPNLTIV NPTTHFETPQ TETAKKISHL KTELKFFKVL ESYSRLLEKG GMYFRDLKFQ
     GKPYLTKEKI AEIYYSFNEN YHLANRVDST KEKLMHMLNS RITPETKKSW VSKLIEGMDK
     EQLQTLYDRP DQEFESSDAE YKFLSRKIVT QALKPVGKGI NRMRFFNIQA QYLHFLKQVP
     NLVKLADYGL TLEQWQTGLE EVQANFKNHE INLDDVTPFL FLFDLITGKN GDRSMRFIFI
     DEIQDYTPFQ LAYLQNRFPK AKFTMLGDLN QAIFTRTESR SLLSQVQKLF DRDKTEVVQL
     TRSYRSTKPI TEFTRAILKN GQKIDTFERE GDLPNVMVKN DELALQEGLL AQLKSNDERK
     ITTAIICKTK LESEAVAKYL QLQDYPATLI RSENQRLAAG TLVIPAYLAK GLEFDAVILW
     DLSAKNYPDE DDRQLVYTVA SRAMHRLTIF AKDQVTPILD AVSKQLYVQE
//