ID A0A0R2D1R3_9LACO Unreviewed; 778 AA.
AC A0A0R2D1R3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN ORFNames=FC19_GL001291 {ECO:0000313|EMBL:KRM95812.1};
OS Liquorilactobacillus aquaticus DSM 21051.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Liquorilactobacillus.
OX NCBI_TaxID=1423725 {ECO:0000313|EMBL:KRM95812.1, ECO:0000313|Proteomes:UP000051015};
RN [1] {ECO:0000313|EMBL:KRM95812.1, ECO:0000313|Proteomes:UP000051015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21051 {ECO:0000313|EMBL:KRM95812.1,
RC ECO:0000313|Proteomes:UP000051015};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRM95812.1}.
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DR EMBL; AYZD01000018; KRM95812.1; -; Genomic_DNA.
DR RefSeq; WP_057876277.1; NZ_AYZD01000018.1.
DR AlphaFoldDB; A0A0R2D1R3; -.
DR STRING; 1423725.FC19_GL001291; -.
DR PATRIC; fig|1423725.3.peg.1329; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000051015; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000313|EMBL:KRM95812.1};
KW Cell division {ECO:0000313|EMBL:KRM95812.1};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 441..637
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 279..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 458..465
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 778 AA; 86036 MW; 67B46E040EBEC7E4 CRC64;
MAQRKRKRRT TSKKSEFISK RTSGGLFILV GLLGLLKLGY VGILCINIFR LFIGDAYVVG
EIALIVFGVY LLLTDEEPHF EKHYWGGASI VLASVLLFLH SLFFQQLDLH SNFISITWQY
LRADIAAGSI GSRIGGGLLG ALLYTPSYFL FAQVGTYIIV GLLLVIGICV FSGFPLSRVL
EFCGKVLYQV MAFVRSVFAL LFNYIHRMFF KLYKKMVGLR KRRVGKSRNK KIIEKPDIIK
PQKAQKESLT EKPVEIARDT EAIKTNTWNT GMEQAENMRD SQETAPKEQG KKAGVTFTDN
PVNDDYELPP TTLLQRVEPT DQSDEYQKIE KNTQVLKKTF NSFGVDVDIK SAILGPAVTK
YELHPAIGVK VSKIVNLADD LALALAAKDI RIEAPIPGKS LIGIEVPNQK VSTVSFRDII
EAQKKQKSKP LEVPLGRDIS GKLVTADLSK MPHLLIAGST GSGKSVAING IITSLLMNCP
PHLVKLMLVD PKKVELGVYN GVPHLLTPVV TNPKKASKAL HKLVAEMERR YELFANTGQR
NIAGYNDMIQ RQNNETGSEE PVLPYIVIVV DELSDLMMVA ANEVEDAIIR LAQMARAAGI
HMILATQRPS VDVITGLIKA NVPSRISFAV SSGTDSRTII DTNGAEKLLG RGDMLFLPMG
LNKPIRVQGA FISDNDVASV VDFVKQQQTA EYDESLIVSD EETAQDEGED SDDELFSEAV
QLIVKEQACS ISMLQRRFRI GYNRAARLVD EMEAKGMVGP SEGSKPRKVY LNNDDPSQ
//
