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Database: UniProt
Entry: A0A0R2D540_9LACO
LinkDB: A0A0R2D540_9LACO
Original site: A0A0R2D540_9LACO 
ID   A0A0R2D540_9LACO        Unreviewed;       464 AA.
AC   A0A0R2D540;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Na(+) H(+) antiporter {ECO:0000313|EMBL:KRM98993.1};
GN   ORFNames=FC24_GL000630 {ECO:0000313|EMBL:KRM98993.1};
OS   Loigolactobacillus rennini DSM 20253.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Loigolactobacillus.
OX   NCBI_TaxID=1423796 {ECO:0000313|EMBL:KRM98993.1, ECO:0000313|Proteomes:UP000051638};
RN   [1] {ECO:0000313|EMBL:KRM98993.1, ECO:0000313|Proteomes:UP000051638}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20253 {ECO:0000313|EMBL:KRM98993.1,
RC   ECO:0000313|Proteomes:UP000051638};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC       family. {ECO:0000256|ARBA:ARBA00038435}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRM98993.1}.
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DR   EMBL; AYYI01000021; KRM98993.1; -; Genomic_DNA.
DR   RefSeq; WP_057873447.1; NZ_AYYI01000021.1.
DR   AlphaFoldDB; A0A0R2D540; -.
DR   STRING; 1423796.FC24_GL000630; -.
DR   PATRIC; fig|1423796.3.peg.647; -.
DR   OrthoDB; 9762978at2; -.
DR   Proteomes; UP000051638; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR   PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR   PANTHER; PTHR33451:SF6; NA(+)/H(+) ANTIPORTER NHAC; 1.
DR   Pfam; PF03553; Na_H_antiporter; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051638};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        35..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        114..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        147..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        235..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          162..452
FT                   /note="Na+/H+ antiporter NhaC-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03553"
SQ   SEQUENCE   464 AA;  49204 MW;  FC44AB4D8AE1ACD0 CRC64;
     MQNKIRPLSF WEAVIVLILV LGIMGVGVIG LGISPQVPVM LALGFVIVWA RWRHVDWATV
     NVGVVEGIEK GIIPIFIFIL IGAMISTWIA AGTIPTLMVI GFKLISVKWF LPSVFIACAL
     VGMAVGSTFT VVSTVGLACF GMGLTMGLNP ALVAGTIISG SVFGDKLSPL SETNNLTSAV
     MGLNLFTHMR NLFWSIFPAG AISLILVTIL GHTTATVSWT RIQQTVTVLQ QSFKLSFLAL
     VPIILIFACV ILKMPAIPTM LLNIFVSAVL LLIEHPNLAL KHLAHIITDG YVAHTSSASV
     NQLLSRGGII SMMPTVALIV LTLSLGGLLV KFGLIEAVMT PIAEKLTSDG KLVFAALAAS
     IGVNLFVGEQ FLSIILPGRA FKTAFQQGGL TNGALGRVLE DGGTVVNYLV PWSVGGVFLA
     NTLGVATIDY LPFTFFSLLC PVMSLISGFA GIGLQHLKPQ LKSL
//
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