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Database: UniProt
Entry: A0A0R2D5K4_9LACO
LinkDB: A0A0R2D5K4_9LACO
Original site: A0A0R2D5K4_9LACO 
ID   A0A0R2D5K4_9LACO        Unreviewed;       710 AA.
AC   A0A0R2D5K4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   10-APR-2019, entry version 17.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   ORFNames=FC19_GL001759 {ECO:0000313|EMBL:KRM95622.1};
OS   Lactobacillus aquaticus DSM 21051.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1423725 {ECO:0000313|EMBL:KRM95622.1, ECO:0000313|Proteomes:UP000051015};
RN   [1] {ECO:0000313|EMBL:KRM95622.1, ECO:0000313|Proteomes:UP000051015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21051 {ECO:0000313|EMBL:KRM95622.1,
RC   ECO:0000313|Proteomes:UP000051015};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O.,
RA   Ritari J., Douillard F.P., Paul Ross R., Yang R., Briner A.E.,
RA   Felis G.E., de Vos W.M., Barrangou R., Klaenhammer T.R.,
RA   Caufield P.W., Cui Y., Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through
RT   comparative genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRM95622.1}.
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DR   EMBL; AYZD01000023; KRM95622.1; -; Genomic_DNA.
DR   RefSeq; WP_057876499.1; NZ_AYZD01000023.1.
DR   EnsemblBacteria; KRM95622; KRM95622; FC19_GL001759.
DR   PATRIC; fig|1423725.3.peg.1806; -.
DR   OrthoDB; 304844at2; -.
DR   BioCyc; GCF_001436755:G1EOF-1734-MONOMER; -.
DR   Proteomes; UP000051015; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000051015};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    280    298       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    343    367       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    422    446       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    452    472       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    511    532       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    552    577       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    584    602       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    608    627       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    639    659       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    665    689       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN        1    162       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
SQ   SEQUENCE   710 AA;  79630 MW;  10AC3A230C66CC6B CRC64;
     MTVIALAGNP NSGKTTLFNR LTGSNQYVGN WPGVTVERKE GKLKNDKSVI VQDLPGIYSL
     SPYTAEEVVT RKYLLDDVPS LVVDTVDATN IERNLYLTLQ LMETGVPLVL ALNMIDVLKK
     HGRKVNVKKL SYMLSVPVVG VSALKRTNID KLESEIERSL NKKERYPIPE YDERLEAALE
     MICADIQGLV PSESVRWYAI KFFERDERVW NEIKLDATRK EDIEHVIETA EKLFEDNSDS
     IVVNARYEYI ARIINMCVID EKNFTMSMSD RVDEIVTNRW LAFPIFMGVM WVVYYLSIQT
     IGTMGSDWVN DVLFGEWIPN FADNLLKSWN VAPWMNGLVV EGIIGGIGSV LGFVPQIMML
     FLCLGILEDC GYMARIAFVM DRIFHRFNLS GKSFIPMLIS TGCGVPGIMS TRTIENDKDR
     RMTIMLTTFM PCSAKLVVIA MIAGTFFSGQ SWVAPSAYFL GMLAVVISGI FLKKTKLFSG
     PPLPFVMELP AYHLPKPDNV LRQVESRAKG FIQKAGTIIF ASCVLIWFLV NFNFKFQMTS
     QNHSMLRYMG EFIAPIFAPL GFGDWHATVA VIAGLIAKEN CVGTLRIAFG GGSVASFTNA
     LQSTYSSMGA YAFLAFNLLC APCFAAIGTM HKEYGDIKWT LYALGYQTGL AYLISMFIYQ
     MSQIIQLRIT VESVSLSLFV IIIIIYALFI KKDENEKLYS VEKMAVGGKI
//
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