ID A0A0R2DIA8_9LACO Unreviewed; 750 AA.
AC A0A0R2DIA8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Metallo-beta-lactamase superfamily hydrolase {ECO:0000313|EMBL:KRN02811.1};
GN ORFNames=FD13_GL001530 {ECO:0000313|EMBL:KRN02811.1};
OS Levilactobacillus senmaizukei DSM 21775 = NBRC 103853.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Levilactobacillus.
OX NCBI_TaxID=1423803 {ECO:0000313|EMBL:KRN02811.1, ECO:0000313|Proteomes:UP000051589};
RN [1] {ECO:0000313|EMBL:KRN02811.1, ECO:0000313|Proteomes:UP000051589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21775 {ECO:0000313|EMBL:KRN02811.1,
RC ECO:0000313|Proteomes:UP000051589};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN02811.1}.
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DR EMBL; AYZH01000004; KRN02811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2DIA8; -.
DR STRING; 1423803.FD13_GL001530; -.
DR PATRIC; fig|1423803.3.peg.1576; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000051589; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:KRN02811.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 498..700
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 750 AA; 84298 MW; 1CD3E22EC23D2DBC CRC64;
MPAAWFFFGL TLAAVSVTGG GHFWGGCGLL ALILLRVISL KSRRVLCTVL IGGGLFGGWL
WLQQQQLDRW RLAMGAKQTQ ALEIRVQPDA MVVRGTSYYF VGRDQTHHDW VTVHGQLRTP
HEQTTLQNVD RAMLWRVTGE ISGILPATNF NQFDAARYWS HRRIVRSVKV TAVNSRSPSG
ATIWQYWSDW WHHWRSQLIH YCERLPGALS VYALGLFPGN KSVAFADEMQ GMQQLGLLHL
FAISGLHVVL LLTVLEWLAV RLHLPREWWE WGLFVCLPGY LILAGGGSGV LRACLMHGSQ
LLGKRCGYRL DRLTGWSIAL VVGLIVNPGL LFELGGQLSY GLSLGLILWA RESLVWRQLG
LTLLSLPGIL TAFFQWHVLT LLANWLVVPL FPSVILPLTV VGTVCFSWFP RVSVACSWLL
GSFDQGLRMV GRLPGNILFG KPVWWIAWLW VVLTWQLFSR PVRARRLWLI GLFVIYSGMY
GWNHWPVTGE VAYFDVGQGD SILWREPFNR RVSLIDTGGR LAFPQPTWAT RAPVRYGAER
TSINYLHSRG IHRIDDLYLT HHDADHIGDL PAFIKQMQIK RLLVPAGMEQ EPSWQRGLHL
SGIRVQPIKV GVALPVVVRH PYESAPAENA NSLALQTQAG GLNFLFMGDL DRPGEQKMMA
ADSQLRTDVL KLGHHGSKTA SAPAFIQQLR PRLAIISAGR DNRYGHPNPE TLTTLAQAHL
PALSTQTSGM IRYVYRGNWG QWQTKLGGRP
//