ID A0A0R2DTD3_9LACO Unreviewed; 933 AA.
AC A0A0R2DTD3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=3'-5' exonuclease DinG {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
GN Name=dinG {ECO:0000256|HAMAP-Rule:MF_02206,
GN ECO:0000256|RuleBase:RU364106};
GN ORFNames=FC86_GL000851 {ECO:0000313|EMBL:KRN03740.1};
OS Holzapfeliella floricola DSM 23037 = JCM 16512.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Holzapfeliella.
OX NCBI_TaxID=1423744 {ECO:0000313|EMBL:KRN03740.1, ECO:0000313|Proteomes:UP000051378};
RN [1] {ECO:0000313|EMBL:KRN03740.1, ECO:0000313|Proteomes:UP000051378}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23037 {ECO:0000313|EMBL:KRN03740.1,
RC ECO:0000313|Proteomes:UP000051378};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- FUNCTION: 3'-5' exonuclease. {ECO:0000256|HAMAP-Rule:MF_02206,
CC ECO:0000256|RuleBase:RU364106}.
CC -!- SIMILARITY: Belongs to the helicase family. DinG subfamily. Type 2 sub-
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_02206,
CC ECO:0000256|RuleBase:RU364106}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN03740.1}.
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DR EMBL; AYZL01000020; KRN03740.1; -; Genomic_DNA.
DR RefSeq; WP_056975055.1; NZ_AYZL01000020.1.
DR AlphaFoldDB; A0A0R2DTD3; -.
DR STRING; 1423744.FC86_GL000851; -.
DR PATRIC; fig|1423744.4.peg.875; -.
DR OrthoDB; 9803913at2; -.
DR Proteomes; UP000051378; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR HAMAP; MF_02206; DinG_exonucl; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR006310; DinG.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR01407; dinG_rel; 1.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR30231; DNA POLYMERASE III SUBUNIT EPSILON; 1.
DR PANTHER; PTHR30231:SF4; PROTEIN NEN2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_02206};
KW Exonuclease {ECO:0000256|HAMAP-Rule:MF_02206,
KW ECO:0000256|RuleBase:RU364106}; Helicase {ECO:0000313|EMBL:KRN03740.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02206};
KW Nuclease {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_02206}; Reference proteome {ECO:0000313|Proteomes:UP000051378}.
FT DOMAIN 247..507
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT MOTIF 459..462
FT /note="DEAH box"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02206"
FT BINDING 285..292
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02206"
SQ SEQUENCE 933 AA; 107429 MW; CD00D86E84CD3DFE CRC64;
MPKKATTYAV VDLETTGTHR EAQDRVIQFG CAIIQKQKIV KTYSFLINPG REIPERITRL
TGITDGDVKD APRFEDIALK LYKILKGTIF VAHNVNFDLP FLNYELEKAG ISPLTNKAID
TVELSQILLP TCESFKLNDL AKSLNIKHTN PHQADSDAIV TAKLLMKLQR KARQLPFETL
KLLSELGKGL TRETGGFFRA IYNYKKRRPQ TLDNQYFKIK ELVLKKQYHV TPESTDLTDY
PIDDSCKKSL FKGKIRFRRS QVNMMNRIHD FLQIKNRHKP LFVEAPNGSG KTFAYLFSYV
HQLLPMQKLV VATPTTILQN QIVQTEVPQL NRILKTKFKA EIVKSSHYYL DLDAFYQTLS
KDNQTNYTLT LQLKILVWLL QTDTGDLSEL QLTNYQDLLF NVIRHPGDAR NATTFSDYDF
FNLSRERQEQ ADILITNHAY LVNHANDMIW GQTPLLVVDE AHRFAENTTH SLSDGFQFES
LWGQLSHMQS LLTNQQIGLL NGFKQDLFMS KEINQTHASL EKLIKVINEF QRFLYQGIKT
AGVPIYRSLK QTDFAVNGNE LFQDKIIAQS YLTRLQGQLE TVRRKTLTLK TQLAQQRYRL
LKNECEAIDE LNKLVIVIET YLQKCYSLNG EINKEKDLND LGFVLQSSKV DNPLAVNLRW
LLIDPIEPIQ DILKSFSRPL FISATLKQQD DFSYTLSSLG YQKQDVQTYV AKATGRYRDN
VKIVGVNDLN GIKNPNDDQY LENISELIPD IISASDSHHI LLLFTNLDNI KDVYYHILND
ERLSEYEVLA QGVTGSNEKI SKRYTIATKS ILLGANSYWE GVDFKKVQHD MVIVTQLPFE
SPDRADVKLR QNNLTNPFKE DTLPRALIRF QQGFGRLARK ENSKGVFVVL DPRFYESPYA
TLFQKSLHKL PIKFLDNSQL VNYLKQTSNR GKQ
//
