ID A0A0R2FCE4_9LACO Unreviewed; 695 AA.
AC A0A0R2FCE4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Cell division protein FtsI {ECO:0000313|EMBL:KRN22922.1};
GN ORFNames=FD14_GL000760 {ECO:0000313|EMBL:KRN22922.1};
OS Secundilactobacillus similis DSM 23365 = JCM 2765.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Secundilactobacillus.
OX NCBI_TaxID=1423804 {ECO:0000313|EMBL:KRN22922.1, ECO:0000313|Proteomes:UP000051442};
RN [1] {ECO:0000313|EMBL:KRN22922.1, ECO:0000313|Proteomes:UP000051442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23365 {ECO:0000313|EMBL:KRN22922.1,
RC ECO:0000313|Proteomes:UP000051442};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN22922.1}.
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DR EMBL; AYZM01000091; KRN22922.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2FCE4; -.
DR STRING; 1423804.FD14_GL000760; -.
DR PATRIC; fig|1423804.4.peg.814; -.
DR Proteomes; UP000051442; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KRN22922.1};
KW Cell division {ECO:0000313|EMBL:KRN22922.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000051442}.
FT DOMAIN 72..299
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 349..673
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 74744 MW; 07AE1EA577BD6887 CRC64;
MKNFFNRFTQ NQSRRGKTTT TSQIPFRMNF LFIIVGLLFV ALIAQLAYLQ ILHGTQLKAE
VNRTDSTVET NNVQRGMVFD STGRVLVGNK SHQAISYTKG VNVLSGDMYR IANRLGKYLT
VSTGSLTTRN QADYYLASDK RLKSVEAKIP HINEYSTSTA YDKALNYVLN HPAQYKLTHQ
QANDATIYAK MSGAYSLSTT YIKETGVTSK ELSEVGEHLG EMPGVKVGTS WTRDYPYGSS
LKSIIGTVSS EKVGLPDNKV NQFLAQGYSR NDSVGQSYLE EQYESVLRGT KSQTQVEVSG
TKIMKEVKKY GGKKGDNLQL TINAGFQKKL QSLVRTASTN ASGNSTGVYA VVMNPKNGAV
IGMAGVDRNP STGKVTNNAL GTINSSITMG SVVKGAMISG ALMDGVITPS NNTLTDMPIT
VGGVKKASWF NKNGGANMAV NASTALEVSS NSYMMQLAMK EAGFQYSSGA ALTMNTSIFS
KLRGYFNQFG LGVKTGIDLP GETTGIAGSS SKAHIGNALD ESFGNYDAYT TMQVAQYMST
IANGGYRIQP HVLGSIRGTN KNGGLGAVKA SVTPTVLNEI NMTSAERKLV TEGLYDVVHG
TNTYKTGAEL SSIKPEISAK TGTAQTYYKG TETVTLSLAS YAPSTNPQVV LALAMPNLDY
NAEDNNMKLA KQIYAAYWSM VQSTSTINSS SSSSY
//
