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Database: UniProt
Entry: A0A0R2FHM2_9LACO
LinkDB: A0A0R2FHM2_9LACO
Original site: A0A0R2FHM2_9LACO 
ID   A0A0R2FHM2_9LACO        Unreviewed;       828 AA.
AC   A0A0R2FHM2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=ATP-binding protein {ECO:0000313|EMBL:KRN23892.1};
GN   ORFNames=FD14_GL000647 {ECO:0000313|EMBL:KRN23892.1};
OS   Secundilactobacillus similis DSM 23365 = JCM 2765.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Secundilactobacillus.
OX   NCBI_TaxID=1423804 {ECO:0000313|EMBL:KRN23892.1, ECO:0000313|Proteomes:UP000051442};
RN   [1] {ECO:0000313|EMBL:KRN23892.1, ECO:0000313|Proteomes:UP000051442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23365 {ECO:0000313|EMBL:KRN23892.1,
RC   ECO:0000313|Proteomes:UP000051442};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC       involved in the recovery of the cell from heat-induced damage, in
CC       cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the
CC       processing of protein aggregates. Protein binding stimulates the ATPase
CC       activity; ATP hydrolysis unfolds the denatured protein aggregates,
CC       which probably helps expose new hydrophobic binding sites on the
CC       surface of ClpB-bound aggregates, contributing to the solubilization
CC       and refolding of denatured protein aggregates by DnaK.
CC       {ECO:0000256|ARBA:ARBA00025613}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRN23892.1}.
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DR   EMBL; AYZM01000087; KRN23892.1; -; Genomic_DNA.
DR   RefSeq; WP_054734074.1; NZ_BBAD01000011.1.
DR   AlphaFoldDB; A0A0R2FHM2; -.
DR   STRING; 1423804.FD14_GL000647; -.
DR   PATRIC; fig|1423804.4.peg.694; -.
DR   OrthoDB; 9803641at2; -.
DR   Proteomes; UP000051442; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051442};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}.
FT   DOMAIN          1..147
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   DOMAIN          423..458
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   REGION          148..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          419..468
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   828 AA;  91959 MW;  682389CE7572FF03 CRC64;
     MDNLFTPSAK SVLALAQEQA KFFKHQAVGT EHLLLALTIE KNGIANKVLQ QFSISEDDVR
     EEIERFTGYG TLGNVDKDTY LPYSPKAKDM LSVAGEEAKR IGATKIGTEH LLLALLSDET
     ILSSRILMNL NIDLGQARKV ILRKLGVSET QDKRRNPRAR KQQGGTPTLD SLARDLTQLA
     KDDRMDPTVG RNKEVRRVIQ ILSRRTKNNP VLIGEPGVGK TAIAEGLAQR IVAGDVPEDM
     QQKRLMALDM GSLVAGTKYR GEFEDRLKKV IEEIYNDGQV ILFIDELHTL IGAGGAEGAI
     DASNILKPAL ARGELQTIGA TTLDEYQKYI ESDAALERRF ATVQVDEPTE DETIEILKGL
     RPRYEEHHHA NISDEALEQA VKLSTRYITD RFLPDKAIDL MDEAAAKVRI SQMDQPSAKS
     KQEAKLAELA DQREAAILDQ RFEEAADLRE QEIALKAKLD KKAKKKAESD QQYDLNVTGE
     DVAEVVSDWT GVPTTQLQRT EQERLINLEN ILHKRVVGQE EAVSAVSRAI RRARSGLKDP
     NRPIGSFMFL GPTGVGKTEL AKALAEAMFG SEDNIIRVDM SEYMEKYSTS RLIGSAPGYV
     GYDEGGQLTE KVRQKPYSVV LFDEVEKAHP DVFNLLLQVL DDGYLTDSKG RKVDFRNTIL
     IMTSNLGATR LRDEKTVGFG AEDHAEDYKA MAATIRETLK QSFRPEFLNR IDEIVVFHAL
     VKKELHQIVK LMAKTVIKRI SDQGIKVKVT PAAIDVIADA GFDPEYGARP IRRALQTKIE
     DRLSEALLSG EIKAGNQVTL GATKGEITVN VKQETEKPVE KSQPVGTK
//
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