ID A0A0R2FKW4_9LACO Unreviewed; 410 AA.
AC A0A0R2FKW4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Hydroxymethylglutaryl-CoA reductase {ECO:0000313|EMBL:KRN25815.1};
GN ORFNames=FC75_GL002355 {ECO:0000313|EMBL:KRN25815.1};
OS Lacticaseibacillus camelliae DSM 22697 = JCM 13995.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=1423730 {ECO:0000313|EMBL:KRN25815.1, ECO:0000313|Proteomes:UP000050865};
RN [1] {ECO:0000313|EMBL:KRN25815.1, ECO:0000313|Proteomes:UP000050865}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22697 {ECO:0000313|EMBL:KRN25815.1,
RC ECO:0000313|Proteomes:UP000050865};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN25815.1}.
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DR EMBL; AYZJ01000004; KRN25815.1; -; Genomic_DNA.
DR RefSeq; WP_056988775.1; NZ_AYZJ01000004.1.
DR AlphaFoldDB; A0A0R2FKW4; -.
DR STRING; 1423730.FC75_GL002355; -.
DR PATRIC; fig|1423730.4.peg.2443; -.
DR Proteomes; UP000050865; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR Gene3D; 1.10.8.660; -; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000050865}.
SQ SEQUENCE 410 AA; 41845 MW; B6F64733F95B1073 CRC64;
MTKFYEKTPA ARRQQLIEEG ILSNRGADCL AEKGLDDAVA ANLIENQIGQ FALPLGVVRN
LTVNGTVRQL AMVTEEPSVV AAASNGARLA NLNGGVKASA GPHRVIAEVV FDDVADFDAA
SRMIDQHREM LFAVANAAHP SAVKRGGGLK QITCEQRDRF LILQLTIDPS QAMGANLANT
IAEAVAAAAA GLLDQPVLVA ILTNGSSELV SAEVTLDPST IATAPGNGAT IAEKIAALSD
LAQCDPLRAA THNKGIMNGV EAAVLATGND TRAVAAAVGA YTQGKALSTW QLAGGQLVGH
IKLPLPVGVV GGAISALPKA QAALSMGGIR TVADLQMSLA ALGLVQNLAA LRALAGPGIQ
AGHMALQARA LAIAAGATGD EIAAVADRLP AQARDLASAR KVLEELRGKH
//
