ID A0A0R2FN96_9LACO Unreviewed; 702 AA.
AC A0A0R2FN96;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN ORFNames=FD14_GL002265 {ECO:0000313|EMBL:KRN26362.1};
OS Secundilactobacillus similis DSM 23365 = JCM 2765.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Secundilactobacillus.
OX NCBI_TaxID=1423804 {ECO:0000313|EMBL:KRN26362.1, ECO:0000313|Proteomes:UP000051442};
RN [1] {ECO:0000313|EMBL:KRN26362.1, ECO:0000313|Proteomes:UP000051442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23365 {ECO:0000313|EMBL:KRN26362.1,
RC ECO:0000313|Proteomes:UP000051442};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN26362.1}.
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DR EMBL; AYZM01000036; KRN26362.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2FN96; -.
DR STRING; 1423804.FD14_GL002265; -.
DR PATRIC; fig|1423804.4.peg.2458; -.
DR Proteomes; UP000051442; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051442};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 445..650
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 702 AA; 78483 MW; 1D8F8786917FA248 CRC64;
MVLVGFGGWF YHQQQLMATG HLPTTTRTQL IVQVQPDDVR IGPDSVQLRG KLPSGYWIEG
RFYADNSQLE AYRLRQTSQM MLTGDVDRYA PATNVNEFDF GAYQAHRWTF NQIKIIQLQQ
LTPVQARNPW TIWVNGCHAL RYWLIERTKS LPETLRLYVQ GLFLGYRADG FYERLAAVKD
LGLIHLFSIS GFHVIWLVAL IEWGMALLRL PQGLRVIGLC LILPSYVIIA GGGPGVIRAV
LVVLIGILAK LGRVSLSRLT VWGLSLLIGL AISPAMLTEL GGQLSYGLAF SLIFLNQRSL
LFQTLMLNLI SLPTILYHIY QWHVLSLFVN LLLLPLFSWL VFPVVFGLMW LGPSWPVAAG
MGERGLQGLT FSLDWVAQLP GMVVTGQPTA LMTTGLCVLT FMILAAQTAR IRRWLFGLLI
VSYAGLMFWR QHPLDGEVTF FDIGQGDSFL IREPGNRQVI MIDTGGKVTF GSHRPTGRST
AERVSINYLK SLGITQIDHL LLSHQDADHT GDVDDVLAAL VVKRLYVPLG MTSNERFMKR
VQPALMKHRT QVIEVQAGQS IEGTQLQVVH PFKAGEGTNE DSMVLFANYG QLSWLFTGDL
DQAGERQIAA HFPQLTVDVL KLGHHGSKTS SDPTVVAKWQ PKIGIISAGR ENRYGHPNQE
TLATLAKQQV PYFSTQQNGM VTYRFRAHAP GYWQTFLKGA FS
//
