ID A0A0R2HVE1_CARDV Unreviewed; 227 AA.
AC A0A0R2HVE1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Antiholin-like protein LrgB {ECO:0000256|HAMAP-Rule:MF_01142};
GN Name=lrgB {ECO:0000256|HAMAP-Rule:MF_01142};
GN ORFNames=IV74_GL001897 {ECO:0000313|EMBL:KRN54316.1};
OS Carnobacterium divergens DSM 20623.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Carnobacterium.
OX NCBI_TaxID=1449336 {ECO:0000313|EMBL:KRN54316.1, ECO:0000313|Proteomes:UP000051658};
RN [1] {ECO:0000313|EMBL:KRN54316.1, ECO:0000313|Proteomes:UP000051658}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20623 {ECO:0000313|EMBL:KRN54316.1,
RC ECO:0000313|Proteomes:UP000051658};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- FUNCTION: Inhibits the expression or activity of extracellular murein
CC hydrolases by interacting, possibly with LrgA, with the holin-like
CC protein CidA. The LrgAB and CidA proteins may affect the proton motive
CC force of the membrane. May be involved in programmed cell death (PCD),
CC possibly triggering PCD in response to antibiotics and environmental
CC stresses. {ECO:0000256|HAMAP-Rule:MF_01142}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01142};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01142}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CidB/LrgB family. LrgB subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01142}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN54316.1}.
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DR EMBL; JQBS01000035; KRN54316.1; -; Genomic_DNA.
DR RefSeq; WP_034569692.1; NZ_JQLO01000001.1.
DR AlphaFoldDB; A0A0R2HVE1; -.
DR GeneID; 56818681; -.
DR PATRIC; fig|1449336.4.peg.1934; -.
DR eggNOG; COG1346; Bacteria.
DR Proteomes; UP000051658; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01142; LrgB; 1.
DR InterPro; IPR024891; Antiholin-like_LrgB.
DR InterPro; IPR007300; CidB/LrgB.
DR PANTHER; PTHR30249:SF0; PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR30249; PUTATIVE SEROTONIN TRANSPORTER; 1.
DR Pfam; PF04172; LrgB; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01142};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852, ECO:0000256|HAMAP-Rule:MF_01142};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01142};
KW Reference proteome {ECO:0000313|Proteomes:UP000051658};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01142};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01142}.
FT TRANSMEM 6..21
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01142"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01142"
FT TRANSMEM 60..77
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01142"
FT TRANSMEM 86..109
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01142"
FT TRANSMEM 142..165
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01142"
FT TRANSMEM 177..195
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01142"
FT TRANSMEM 201..225
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01142"
SQ SEQUENCE 227 AA; 23944 MW; 153729BA321A637C CRC64;
MTPYFGIIVS MVAFGIGTFL FKKSKGFFLF TPLFVAMVLG ILFLKVGHFS YEEYSSGGKM
ISFFLEPATI AFAIPLYKQV DVLKKYWVQI VSAIIVGSFG SVVVVYLLSG VIHVDHSIMA
SLLPEASTTA IAVPLSESIG GIAAITSFAV IFNAVIVYAL GRFLLEKFNI KNPIARGLAL
GASGHALGVA VGIELGEVEA AMASIAVVVV GVVTVIVVPA FAVFIGL
//
