ID A0A0R2IZV2_9LACO Unreviewed; 624 AA.
AC A0A0R2IZV2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Sodium hydrogen exchanger {ECO:0000313|EMBL:KRN67229.1};
GN ORFNames=IV80_GL000764 {ECO:0000313|EMBL:KRN67229.1};
OS Pediococcus cellicola.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Pediococcus.
OX NCBI_TaxID=319652 {ECO:0000313|EMBL:KRN67229.1, ECO:0000313|Proteomes:UP000051568};
RN [1] {ECO:0000313|EMBL:KRN67229.1, ECO:0000313|Proteomes:UP000051568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17757 {ECO:0000313|EMBL:KRN67229.1,
RC ECO:0000313|Proteomes:UP000051568};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN67229.1}.
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DR EMBL; JQBR01000002; KRN67229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2IZV2; -.
DR STRING; 319652.IV80_GL000764; -.
DR PATRIC; fig|319652.3.peg.770; -.
DR Proteomes; UP000051568; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR43562:SF1; NA(+)_H(+) ANTIPORTER YJBQ-RELATED; 1.
DR PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051568};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 542..622
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 624 AA; 69508 MW; 2EA1DECBCA8AD8C4 CRC64;
MVWEAITMNQ VSLLIMLFAA LVTPMLMARL KLTFLPTAVV EILLGVILGP SLLSLVHATD
ILNQLSDIGV IILLFLSGME IDFDLFKKKQ PTSPLAQKTA AQTSRWSPVI LACLAYGTIM
VISLGLAGIF KWLNLFSDFW LAAILFSTIS LGIVIATLKE NELLSKAFGQ TVLLIAVLGE
VMPLLGLTFY ASVFGNSSKS LWLLFLIIIA AVFLLRRFKF FFNFFEQINK STTQLDIRLA
FFLIVAMVTV ASSVGAENIL GAFIAGIILK LLRPSQSTKD KLDSIGYGFF IPIFFMMSGV
SLNLKTLLND PEALTLIPLF FLAYLIAKLA IFPILKLRFK SANSLAGMSL SAATITMVVA
ILQVASNMHT INSHQSGAFL LAAVLTCVIS PLIFGKTYQP EPEDLKKQVV HFIGTNIFTV
PVAQQLTKGW YQIQMYTDNE KNFRTYNSEV NAHLLANLNP QAMIAQGVFD TDILVVGHFR
AQENYELAKA AKAYGVPRVI VRFEDHNILN EHETELRGLG IEVYNTPEVN IAMLRGLIET
PSTLLILNDT KNTIFEVQVR NRKYTGMEIK NLPFIDQITI SQIFRNYRLI RPGGSTQLEL
NDRIIFSGDK TNTEEIRREL SKIN
//
