ID A0A0R2KM54_9LACO Unreviewed; 561 AA.
AC A0A0R2KM54;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Malate-H+ Na+-lactate antiporter {ECO:0000313|EMBL:KRN90547.1};
GN ORFNames=IV53_GL000189 {ECO:0000313|EMBL:KRN90547.1};
OS Ligilactobacillus ceti DSM 22408.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1122146 {ECO:0000313|EMBL:KRN90547.1, ECO:0000313|Proteomes:UP000051500};
RN [1] {ECO:0000313|EMBL:KRN90547.1, ECO:0000313|Proteomes:UP000051500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22408 {ECO:0000313|EMBL:KRN90547.1,
RC ECO:0000313|Proteomes:UP000051500};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN90547.1}.
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DR EMBL; JQBZ01000002; KRN90547.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2KM54; -.
DR STRING; 1122146.IV53_GL000189; -.
DR PATRIC; fig|1122146.4.peg.191; -.
DR eggNOG; COG1757; Bacteria.
DR Proteomes; UP000051500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051500};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 198..530
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 561 AA; 59920 MW; CBEEBCE1772BB18F CRC64;
MNGRSHQGQI ETFTFVKKFL ADDTGVKEVL VATGKNLGVI TLVPIIITVI LAFVLNDVLL
ALIVGILTGY AIWGASFGTG STISKIGEVF GLSFQTIFHV ATDPFNLQIF GVCFTIGGMV
ELIHSNGGFA ALADSLRRRI DSPKKAALTA QLMGSCLFFD DYANVLITGP TMQTITDSQG
ISREKLAYIV DSTAAPVAGM VVVSSWISAE LVAIKTGLDL AGVHASAYNQ FVGSLPYRTY
NFMALFLIFI TIILGREYGP MLYAERRARI TCKRCKQEVL ESHDEKIEKG CIWSALLPII
TLIIYSVIGF YVDGMSQAIK AGVIDKNAGF SFSYIHLSFS YANTVKIIIQ AALLGAVVAL
VMGCFTKKLK FRAGLKAWLK GAQSIFSTVF VLVLAWCLAK VVGLLGTAYY LVDLVSANVP
YYLLPVVIFI TCCVISFVVG SFGCMAIVMP IALPVVYSAV QSSGLGYAEQ FVFASIAAVL
SGAVFGDNCS PITDTTILSS VGAGCPNIDH VKTQLPYALT AAISAAIFGF LPAGFGISPF
ISLVGCTISC LLTLLFIGKK I
//
