ID A0A0R2KSW0_9LACO Unreviewed; 700 AA.
AC A0A0R2KSW0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:KRN92671.1, ECO:0000313|EMBL:TLQ04663.1};
GN ORFNames=FEZ51_04670 {ECO:0000313|EMBL:TLQ04663.1}, IV81_GL001141
GN {ECO:0000313|EMBL:KRN92671.1};
OS Pediococcus stilesii.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Pediococcus.
OX NCBI_TaxID=331679 {ECO:0000313|EMBL:KRN92671.1, ECO:0000313|Proteomes:UP000051859};
RN [1] {ECO:0000313|EMBL:KRN92671.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18001 {ECO:0000313|EMBL:KRN92671.1};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
RN [2] {ECO:0000313|EMBL:TLQ04663.1, ECO:0000313|Proteomes:UP000305541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAM 18815 {ECO:0000313|EMBL:TLQ04663.1,
RC ECO:0000313|Proteomes:UP000305541};
RA Roder T., Wuthrich D., Sattari Z., Von Ah U., Bar C., Ronchi F.,
RA Macpherson A.J., Ganal-Vonarburg S.C., Bruggmann R., Vergeres G.;
RT "The metagenome of a microbial culture collection derived from dairy
RT environment covers the genomic content of the human microbiome.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN92671.1}.
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DR EMBL; JQBX01000031; KRN92671.1; -; Genomic_DNA.
DR EMBL; VBTH01000006; TLQ04663.1; -; Genomic_DNA.
DR RefSeq; WP_057804343.1; NZ_VBTH01000006.1.
DR AlphaFoldDB; A0A0R2KSW0; -.
DR STRING; 331679.IV81_GL001141; -.
DR PATRIC; fig|331679.3.peg.1156; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000051859; Unassembled WGS sequence.
DR Proteomes; UP000305541; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KRN92671.1};
KW Cell division {ECO:0000313|EMBL:KRN92671.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051859};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..300
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 341..668
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 700 AA; 74658 MW; D0BBC6BC2A02AFEE CRC64;
MKSPKKFRRQ KSELPFRLNL IFFVVSALLL LLVGQLGYLQ ILYGSKLQAE VNRTDNTVET
SNVQRGMIYD STGKVLVGNK AHQAISYTKG VNVLAQDMYD VSNNLGKYLT MDNETTLSST
NVAEYLLADS KRSKYYQEKV AGPDNQKNLS SKAIRSKELD YIKEKNVKLS DKETNAAKIF
KIINGAYQLS TVYIKESGIS SEELSEIGEH LSDMPGVKIS TSWTRSYPEG DNIKTLTGTV
SSTKTGLPSD EVNTLLAEGY ARNDSVGQSY LEKQYEPVLK GSKSQTAVEV SSGNQIVKKV
QKYAGKKGDN LVLTVNSKFQ EEVQKIMTEA SQSAGGESTG GYAVVMNPKT GAVIALAGAD
RDPSTGKMTA NALGTINEPI VMGSVVKGAM ISGALMDGVI STNNNTLIDE PIKVAGTNSK
SSWFNSSGSA NMSVDASKAL EVSSNSYMMQ LAMKEGGLKY SSGVSLAGMN PDVFSKMRGY
FEQFGLGTKT GIDIPGESSG YKGPSGAANI GKALDLSFGN YDAYTTLQVA QYMSTIANGG
YRVAPHVVEQ IRSSQKNGKL GKVQSATSPQ VLNYIGLSSS QKKLITDGLY DVVHGDSKYK
TGGPLAGISP GISAKTGTAQ TTTNGKSTVT LSLASFAPSN DPQVVVALAL PGLGTNAESN
NMEAAKKIYS AYWKYVQSKT TLTNPTKATA ETAAQNLNAN
//
