ID   A0A0R2LPU7_9LACO        Unreviewed;       388 AA.
AC   A0A0R2LPU7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00044137};
DE            EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
DE   AltName: Full=Acetoacetyl-CoA thiolase {ECO:0000256|ARBA:ARBA00030755};
GN   ORFNames=IV54_GL000225 {ECO:0000313|EMBL:KRO03433.1};
OS   Levilactobacillus paucivorans.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Levilactobacillus.
OX   NCBI_TaxID=616990 {ECO:0000313|EMBL:KRO03433.1, ECO:0000313|Proteomes:UP000051906};
RN   [1] {ECO:0000313|EMBL:KRO03433.1, ECO:0000313|Proteomes:UP000051906}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22467 {ECO:0000313|EMBL:KRO03433.1,
RC   ECO:0000313|Proteomes:UP000051906};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRO03433.1}.
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DR   EMBL; JQCA01000094; KRO03433.1; -; Genomic_DNA.
DR   RefSeq; WP_057878796.1; NZ_JQCA01000094.1.
DR   AlphaFoldDB; A0A0R2LPU7; -.
DR   STRING; 616990.IV54_GL000225; -.
DR   PATRIC; fig|616990.3.peg.247; -.
DR   OrthoDB; 9764892at2; -.
DR   Proteomes; UP000051906; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KRO03433.1}.
FT   DOMAIN          5..259
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          268..388
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        89
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        345
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        375
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   388 AA;  40789 MW;  AF34B1BAD5CB9DA9 CRC64;
     MAEEVVIVSA VRTPIGKFGR NFRSVSAVTL GTIAAKAAIK RSGLEPNMIQ QTIFGTVLQA
     GQGQNVARQI ELNAGLPASS TAMTVNQVCG SSLKAIRLGQ GAILMGDADA VLVGGTESMS
     RAPYLSHHAR WGRKFGDLTL TDSLAKDGLT DAFSQVPMGI TVENVAEKFN VSRADQDAFA
     LRSQQKATQA QADHHFDAEI VPVPVDGKTI TQDEAVRTTT SLDQLEALKP AFKTNGTVTA
     GNAAGLNDGA AAMVLMRKSA AIAAGIPYLA TLSGYQESGI DPQIMGYAPV TAIQKVLRDH
     HLTVADIDRF EINEAFAAQS VAITRDLQIP ADRLNVNGGS IALGHPLGAS GTRIVVTLLH
     ELLRTQTHRG LAAMCIGGGM GMTLLVER
//