ID A0A0R2QD43_9ACTN Unreviewed; 571 AA.
AC A0A0R2QD43;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 08-NOV-2023, entry version 28.
DE SubName: Full=Cell division protein FtsK {ECO:0000313|EMBL:KRO45402.1};
DE Flags: Fragment;
GN ORFNames=ABR70_03545 {ECO:0000313|EMBL:KRO45402.1};
OS Actinobacteria bacterium BACL4 MAG-120813-bin39.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1655578 {ECO:0000313|EMBL:KRO45402.1, ECO:0000313|Proteomes:UP000053569};
RN [1] {ECO:0000313|EMBL:KRO45402.1, ECO:0000313|Proteomes:UP000053569}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BACL4 MAG-120813-bin39 {ECO:0000313|EMBL:KRO45402.1};
RA Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA Andersson A.F.;
RT "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination.
CC {ECO:0000256|ARBA:ARBA00024986}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRO45402.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LIBC01000118; KRO45402.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2QD43; -.
DR Proteomes; UP000053569; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000313|EMBL:KRO45402.1};
KW Cell division {ECO:0000313|EMBL:KRO45402.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}.
FT DOMAIN 222..422
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT BINDING 239..246
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRO45402.1"
SQ SEQUENCE 571 AA; 62051 MW; 9536B89A70475E10 CRC64;
RFSGSGIGKL RQRRAQKLVA EDFEVSESPP FETPLVKDLV QEFEPQQEEF EIELEDFDQI
TQPIPIIQPV KHENSRPQQL LLSSDVKYEL PPLDLLRGGP AAKGKSKANE AVVAALKQVF
EQFNVDAQVT GFMRGPTVTR YEVELGNGVK VEAISALSKN IAYAVASGEI RILSPIPGKS
AVGIEIPNSD REIVALGDVL RSPVSSNDTH PMLIALGKDV EGSFLCANLA KMPHLLVAGA
TGAGKSSMIN SLVVSVLMRA TPDEVRMVLI DPKRVELTNY EGVPHLIAPI ITNPKKAADV
LSWVVREMEM RYDDLSVFGF RHIDDFNKAV KAGKVNTPAG SDRVLEPYPY LLVIVDELAD
LMMVAAREVE ESIVRITQLA RAAGIHLVLA TQRPSVDIVT GLIKANVPSR LSFATSSLAD
SRVILDTPGA EKLVGQGDGL FLPMGASKPV RIQGAYISER EIEAVVNHVK SQLQPVYRID
LNAPIKSNVI TDDVGDDLDL LLQAIQLVVS TQFGSTSMLQ RKLRIGFAKA GRLMDLMESR
GIVGPTEGSK ARAVLINAEQ MPDVLESIQG N
//
