ID   A0A0R2QUC1_9ACTN        Unreviewed;       468 AA.
AC   A0A0R2QUC1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KRO53999.1};
GN   ORFNames=ABR78_05650 {ECO:0000313|EMBL:KRO53999.1};
OS   Acidimicrobiia bacterium BACL6 MAG-120910-bin40.
OC   Bacteria; Actinomycetota; Acidimicrobiia.
OX   NCBI_TaxID=1655586 {ECO:0000313|EMBL:KRO53999.1, ECO:0000313|Proteomes:UP000050903};
RN   [1] {ECO:0000313|EMBL:KRO53999.1, ECO:0000313|Proteomes:UP000050903}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BACL6 MAG-120910-bin40 {ECO:0000313|EMBL:KRO53999.1};
RA   Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA   Andersson A.F.;
RT   "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRO53999.1}.
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DR   EMBL; LIBI01000001; KRO53999.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R2QUC1; -.
DR   STRING; 1655586.ABR78_05650; -.
DR   Proteomes; UP000050903; Unassembled WGS sequence.
DR   GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          93..226
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   DOMAIN          238..460
FT                   /note="Malic enzyme NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00919"
SQ   SEQUENCE   468 AA;  49409 MW;  2184DBE37C2F5052 CRC64;
     MTTLPNAAFS IALDCQLDNV PGTLGRLCAA IGEAGGNIGA LDGFDVRGPV LRRSLVVHCR
     NEEHQHAVVA AVQKLDGVTV LDWWDRTFRM HEAGKIEVLS TAPVNDRDDL SMAYTPGVAR
     VCTAIEKDPL LSHKYTIRKN TVAIVSNGTA VLGLGDIGPE GAMPVMEGKA LLFKEFGGVN
     GFPICINART ADEVVDFVQR IAPTFGGINL EDIKAPECFE IEERLRASLD IPVFHDDQHG
     TAVVTLAALW NSLKITGKKM EDLTVVISGV GAAGVAIGKI LLNAGIGDVI GCDRVGAIYT
     GRGEMNSAKE WFAVNTNSSR KMGTISDVIK GADVFVGVSG PDLITAADVR SMAKNPIVFA
     MANPNPEIRP EQVDGLAAVM ATGRSDYPNQ INNVLAFPGI FRGALDANAT DITEGMKLAA
     AIAIAESVTD AQLSPDFVVP SVFDRTIVQR VAPAVAAAAV KDGVIRKS
//