ID A0A0R2T816_9GAMM Unreviewed; 876 AA.
AC A0A0R2T816;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN ORFNames=ABR85_06485 {ECO:0000313|EMBL:KRO83423.1};
OS OM182 bacterium BACL3 MAG-120619-bin3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; OMG group; OM182 clade.
OX NCBI_TaxID=1655593 {ECO:0000313|EMBL:KRO83423.1, ECO:0000313|Proteomes:UP000051242};
RN [1] {ECO:0000313|EMBL:KRO83423.1, ECO:0000313|Proteomes:UP000051242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BACL22 MAG-120619-bin3 {ECO:0000313|EMBL:KRO83423.1};
RA Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA Andersson A.F.;
RT "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRO83423.1}.
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DR EMBL; LICD01000019; KRO83423.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2T816; -.
DR Proteomes; UP000051242; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 609..817
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 876 AA; 94747 MW; 39CA0C611BA3F6F3 CRC64;
MRLLLSAFCL GILSVTWASS LAHIVLWLLW LLGLQILTAI LVVLSRSAFI GAHKSSIAYL
LAVSAAFCGG ALFHAQTADN QLSRQLAPSL EGIPLLIEGR VLNMPTVAGA AYRFQFDVSA
ACLLSDASKT KRPSETVASA DCSAHIPFAG KVLLSYYVPR GLVEKGSVST HEATPLEYPA
KLKPGTFLQL VVKLNRPHGF SNPGGFDYEA FLFRNKILAK GYVRGELTAA LESEMDKTWP
SLSVLIEQRR FDIRKRLLES SANAKNTGIV LALGLGDSSL VSQSLWNQLR ATGTTHLLVV
SGLHVGMIAV FLVMVSRALW RICLVCLPAA ASRAPHCIKF CLWFSLLGTA GFALFTGWSL
PTQRAVAMLT VFAVSRLSSR RFGVITGLLF ALTFVLVLSP LAATGSGFWL SFVAVSVLVL
FAAPPQRPPI EESVNDTPLL SRFSARTRQF AFPQIVVTLG LILPLLVFGV RVSLLAPIIN
LLAIPFLTLA LLPASLLAVL DVALLGQSAL GAIVIADFLC DQLVRLLAVG AELNLLWEPQ
VTPSIASYLV AFVCLCACLV PIGWRARCVC GMWTVMLGLN NLDWRSEAQA GECNQAQPSL
RLDQLDVGQG LALIIRTNCH ALLYDAGASL SAEFEMGSAV IRPALRVLGI NRLDRLVISH
ADNDHAGGAV GVLRSVAVAD IHVGGYAENF STFQGYLGAR AMDARPCRRG DSWRWDGVVF
SYLSPVSQAV GESVGGRRGS QNSRNSHSCV LKVTLGEAAV LLTGDIERAE EASLALRYQE
QLRATVMVAP HHGSKTSSSY ALLKRVDPEI VIVAAGYKNS FGHPHPEVLR RYEILETPVF
NTAVTGMLSL RLDERGVVSP PRAYRLTNRR YWRPIP
//
