ID   A0A0R2T937_9FLAO        Unreviewed;       684 AA.
AC   A0A0R2T937;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Tungsten formylmethanofuran dehydrogenase {ECO:0000313|EMBL:KRO81970.1};
GN   ORFNames=ABR87_00005 {ECO:0000313|EMBL:KRO81970.1};
OS   Cryomorphaceae bacterium BACL7 MAG-121220-bin83.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Cryomorphaceae.
OX   NCBI_TaxID=1655595 {ECO:0000313|EMBL:KRO81970.1, ECO:0000313|Proteomes:UP000051535};
RN   [1] {ECO:0000313|EMBL:KRO81970.1, ECO:0000313|Proteomes:UP000051535}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BACL29 MAG-121220-bin83 {ECO:0000313|EMBL:KRO81970.1};
RA   Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA   Andersson A.F.;
RT   "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRO81970.1}.
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DR   EMBL; LICF01000045; KRO81970.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R2T937; -.
DR   Proteomes; UP000051535; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          350..526
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   684 AA;  75111 MW;  A1D2786AB5FA8D13 CRC64;
     MSKNIHPSLL KAYTLMATAK AMTDLFEANR DVTQTYVHAT SRGHEAIQLA CSLQLKSVDY
     LYPYYRDDAM LLGIGMRPYD LMLQLLAKRD DPFSGGRTYY SHPSLRDDDK PKIPHQSSAT
     GMQAIPAAGA AMGIQYREKQ GLTQEWGDEK PVVVCSIGDA AMTEGEISEA LQMAALKQFP
     LLMLVQDNGW DISASAAETR SGSAVDYAKG FKGLNVVQVD GSDFNASFHA VREVLKNMRK
     TRQPYLIHAK VPLLNHHTSG VRMEWYRDDL EEHGKRDPFP KLHAFLLDEG VALSELESLV
     SQAEKTVAED YALALEAEDP RPEDLFTHRY APTPVTEEKG ERTPVNREKT VMVDSALFAI
     REILAAHPEA LLYGQDVGRR LGGVFREAAT LAQQFGDDRV FNTPIQEAFI VGSTVGMSAV
     GLKPIVEVQF ADYIWPGLNQ LFTELSRSYY LSNGKWAASA VIRVPIGAYG GGGPYHSSSV
     ESVLTNIRGI KVAYPSTGAD LKGLMKAAYA DPNPVVILEH KGLYWSKIPG TEGAKTVEPD
     ADYVIPFGKG RIALEARPHP DGSSLCVVTY GRGVYWAAEA AKHFEGRVEI IDLRTLLPWD
     EALVMERVTA HHRALVVTEE PVVNTFAQAV AGKIQSECFR ALDAPVRVIG SEDTPAIPLN
     KILEAALLPN ADKVRLAIEG LLAY
//