ID A0A0R2TVU5_9ACTN Unreviewed; 293 AA.
AC A0A0R2TVU5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:KRO91292.1};
DE Flags: Fragment;
GN ORFNames=ABS08_05585 {ECO:0000313|EMBL:KRO91292.1};
OS Actinobacteria bacterium BACL4 MAG-120507-bin0.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1655610 {ECO:0000313|EMBL:KRO91292.1, ECO:0000313|Proteomes:UP000051564};
RN [1] {ECO:0000313|EMBL:KRO91292.1, ECO:0000313|Proteomes:UP000051564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BACL1 MAG-120507-bin0 {ECO:0000313|EMBL:KRO91292.1};
RA Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA Andersson A.F.;
RT "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRO91292.1}.
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DR EMBL; LICQ01000277; KRO91292.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R2TVU5; -.
DR Proteomes; UP000051564; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 99..266
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT NON_TER 293
FT /evidence="ECO:0000313|EMBL:KRO91292.1"
SQ SEQUENCE 293 AA; 31883 MW; B51741D27F77BBCF CRC64;
MSDHVVWTEW NDLNVPATFK RLSPATTPID SGDFSKVTFY VPWYMGGKPA LELTKQMPNL
KILQVPNAGY DDAIEYIRPG MTLCNGKTIH NDSTAELAIG LAIASLRGFP DFIRNQDKSE
WISGTFKSLN DRKIGIIGFG SIGATIAKML AGFAVEVVGF TQSGRDNTIA ITDLDKHLPS
LDVVILILPL TKESKHLFDA RRLALMKDGA LLVNVARGGV VETGALIKEL NSGRIAAALD
VTDPEPLPKD HPLWKAKGVL ISPHVGGNTT AFERRARSLI ESQLNLLANN KTL
//
