GenomeNet

Database: UniProt
Entry: A0A0R2UCQ5_9GAMM
LinkDB: A0A0R2UCQ5_9GAMM
Original site: A0A0R2UCQ5_9GAMM 
ID   A0A0R2UCQ5_9GAMM        Unreviewed;       253 AA.
AC   A0A0R2UCQ5;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN   ORFNames=ABS24_09585 {ECO:0000313|EMBL:KRO96958.1};
OS   SAR92 bacterium BACL26 MAG-121220-bin70.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC   Porticoccaceae; SAR92 clade.
OX   NCBI_TaxID=1655626 {ECO:0000313|EMBL:KRO96958.1, ECO:0000313|Proteomes:UP000051213};
RN   [1] {ECO:0000313|EMBL:KRO96958.1, ECO:0000313|Proteomes:UP000051213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BACL26 MAG-121220-bin70 {ECO:0000313|EMBL:KRO96958.1};
RA   Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C., Pinhassi J.,
RA   Andersson A.F.;
RT   "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC         Evidence={ECO:0000256|ARBA:ARBA00000783,
CC         ECO:0000256|RuleBase:RU366031};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRO96958.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LICA01000025; KRO96958.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R2UCQ5; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000051213; Unassembled WGS sequence.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU366031}.
FT   DOMAIN          26..245
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   253 AA;  28213 MW;  39837961B9E0BB3C CRC64;
     MKANRLFDKR VLVVRPLRRQ DDFLLLLEKC SASVIHTPIM TIEPMLDCQQ VKQQILAFDQ
     FDIAIFVSVN AAEIGITWLD QYWPMLPTGM EYFALGGQTA RVVGHYTQAV NYPTNQITSE
     GLLALSQLQN LDNKSVIIFR GGPGRETLKQ ALHSRGARVE YCDLYRRVVD QRQVEVTRQQ
     LTEVDCLVVH SAELLEAIGP ISGFSGAQKV RDLPLVVPSD RVAGIAKSLG YNSITVADSA
     MPESMYGALQ KVF
//
DBGET integrated database retrieval system