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Database: UniProt
Entry: A0A0R2WAU1_9GAMM
LinkDB: A0A0R2WAU1_9GAMM
Original site: A0A0R2WAU1_9GAMM 
ID   A0A0R2WAU1_9GAMM        Unreviewed;       720 AA.
AC   A0A0R2WAU1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   08-MAY-2019, entry version 19.
DE   SubName: Full=Multifunctional fatty acid oxidation complex subunit alpha {ECO:0000313|EMBL:KRP19123.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:KRP19123.1};
DE            EC=4.2.1.17 {ECO:0000313|EMBL:KRP19123.1};
DE            EC=5.1.2.3 {ECO:0000313|EMBL:KRP19123.1};
DE            EC=5.3.3.8 {ECO:0000313|EMBL:KRP19123.1};
GN   Name=fadB {ECO:0000313|EMBL:KRP19123.1};
GN   ORFNames=ABS23_05120 {ECO:0000313|EMBL:KRP19123.1};
OS   SAR92 bacterium BACL16 MAG-120619-bin48.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC   Porticoccaceae; SAR92 clade.
OX   NCBI_TaxID=1655625 {ECO:0000313|EMBL:KRP19123.1, ECO:0000313|Proteomes:UP000051070};
RN   [1] {ECO:0000313|EMBL:KRP19123.1, ECO:0000313|Proteomes:UP000051070}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BACL16 MAG-120619-bin48 {ECO:0000313|EMBL:KRP19123.1};
RA   Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C.,
RA   Pinhassi J., Andersson A.F.;
RT   "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01133165};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-hydroxyacyl-CoA = a (3E)-enoyl-CoA +
CC         H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01123900};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family. {ECO:0000256|SAAS:SAAS00568097}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRP19123.1}.
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DR   EMBL; LIDE01000021; KRP19123.1; -; Genomic_DNA.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000051070; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000051070};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Isomerase {ECO:0000256|SAAS:SAAS00324648,
KW   ECO:0000313|EMBL:KRP19123.1};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   Lyase {ECO:0000256|SAAS:SAAS00999128, ECO:0000313|EMBL:KRP19123.1};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00999134};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00324627,
KW   ECO:0000313|EMBL:KRP19123.1}.
FT   DOMAIN      321    499       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      501    597       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      632    715       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   720 AA;  77646 MW;  D201C3BC775FD5DE CRC64;
     MMFKGTTLSL TKIDNRFAEI NFDNQSESVN KFNSETIADL RSAVALLKQE EGIQGLLLSS
     SKSVFVVGAD ITEFKDMFAE TKANFIAGAQ SVNALFSEIE DLPFPSVAAI NGFALGGGFE
     VCLACDARVI SAKAAVGLPE TGLGIIPGWG GTVRLPRLVG FSTAVHWIAS GEQQRPDAAL
     KAGAVDAVVA PEELRSGALQ LLQEMADGSR DYAARRQQKK SPLAMTEAEL EASASGYRAA
     VVAKVGTHYP ASIKALELVS AAADLDREGA IRLENEAFYD ITRTPQARAM VGLFLSDQYI
     VKQAKNRAHA LADKLEPIKT AAVIGAGIMG GGIAYQNALR GYSVVMKDIN QPALDLGIKE
     ASKLLSKSVA RGKITEDKAA QILSQITPTL LDADLAPCNM VVEAVVELEK VKKQVLPAVE
     ALVPKTAFIT SNTSTISINR LAESLQRPEN FCGMHFFNPV HAMPLVEIIR GEKTSDQTVA
     AVCAYALGLG KKPIVVNDCP GFLVNRVLFA MLFGLEMILA EGGDFQQVDK VMEGWGLPMG
     PAYLMDVIGI DTINHCYPVM IDGLPERFKK TAEVWPTEAI YNAKRFGQKN GVGYYRYELN
     EKGKPGKVVD PEVIAMFASA FGDAKQLAAD EIIERLIVAM AMEMVHCLEE GVVASPAEAD
     MALIYGVGFP TFRGGICRWM DEMGLQTICD LGDKYTAVSE LYRPTEKLRQ MAARGETLYA
//
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