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Database: UniProt
Entry: A0A0R3NMD4_DROPS
LinkDB: A0A0R3NMD4_DROPS
Original site: A0A0R3NMD4_DROPS 
ID   A0A0R3NMD4_DROPS        Unreviewed;      1715 AA.
AC   A0A0R3NMD4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   31-JUL-2019, entry version 19.
DE   SubName: Full=Uncharacterized protein, isoform Q {ECO:0000313|EMBL:KRT01900.1};
GN   Name=Dpse\GA24436 {ECO:0000313|EMBL:KRT01900.1};
GN   ORFNames=Dpse_GA24436 {ECO:0000313|EMBL:KRT01900.1}, GA24436
GN   {ECO:0000313|FlyBase:FBgn0245833};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|EMBL:KRT01900.1, ECO:0000313|Proteomes:UP000001819};
RN   [1] {ECO:0000313|EMBL:KRT01900.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000313|EMBL:KRT01900.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC       ProRule:PRU00841}.
CC   -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00841}.
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DR   EMBL; CM000071; KRT01900.1; -; Genomic_DNA.
DR   RefSeq; XP_015039462.1; XM_015183976.1.
DR   EnsemblMetazoa; FBtr0369513; FBpp0332069; FBgn0245833.
DR   GeneID; 6898302; -.
DR   FlyBase; FBgn0245833; Dpse\GA24436.
DR   Proteomes; UP000001819; Chromosome 3.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR   GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR   GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR   Gene3D; 3.10.20.360; -; 1.
DR   InterPro; IPR032940; CAMSAP.
DR   InterPro; IPR031372; CAMSAP_CC1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR038209; CKK_dom_sf.
DR   InterPro; IPR014797; CKK_domain.
DR   InterPro; IPR011033; PRC_barrel-like_sf.
DR   PANTHER; PTHR21595; PTHR21595; 2.
DR   Pfam; PF17095; CAMSAP_CC1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF08683; CAMSAP_CKK; 1.
DR   SMART; SM01051; CAMSAP_CKK; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF50346; SSF50346; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS51508; CKK; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW   Microtubule {ECO:0000256|PROSITE-ProRule:PRU00841};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819}.
FT   DOMAIN      157    289       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN     1573   1708       CKK. {ECO:0000259|PROSITE:PS51508}.
FT   REGION      334    386       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      411    439       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      468    558       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      575    672       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      811    835       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      902   1000       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1030   1050       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1103   1272       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1288   1325       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1367   1544       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      688    722       {ECO:0000256|SAM:Coils}.
FT   COILED      752    786       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    355    386       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    468    484       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    512    532       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    533    554       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    583    598       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    599    626       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    641    670       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    902    919       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    928    971       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1103   1164       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1165   1199       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1223   1244       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1253   1272       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1309   1325       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1367   1430       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1433   1449       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1468   1530       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1715 AA;  193539 MW;  70B11D49206640C7 CRC64;
     MDAAESQEIR QARQRASVKW LLSKAFNNRV PDNLKEPFYR DHENQERLKP QIIVELGNAT
     LYCQTLSNLY SDPNYQSLNH WSIIQTLARK GVPVAESSDM PITETVLIQT NPLRINAHMS
     VIESLMVLYA KEISSGDRIM SAIRRISGSN YQTPPGQTYE QALLAWISHA CAALKKRIIK
     EVETGLPDEN GTRLQTPDIP PVRDFQDLCD GICLALLIAY YCPKVVPWTM VRINYLPAVE
     DSIHNILLVS NFSQKHLPYG VFHMTPEDVT FMRGSMKLNL VLLLTDLFNL FEIHPAKCVC
     YPGMDGQDVI ARRTLGANEH GICHRRGLTM QPVMPIPDLR SDLDQPPVGS PSNRPPFQVP
     HSNSFSGGLN RRSTPPNEHQ HQQAVVQANS NHFDGNQGEA FVVHKSRGIT TLSSMHSQQQ
     QQHHHQQQHQ QQQQFHQQQQ SQLQQQLQQQ QQQQQQQEPL VPARLRQAKE KTNVESKADE
     RGDFVAAGRP SNWEQSRRPS FAGRRSRRNS SSEDSQLTIE NFGGSQDQLN TLGGRFDRDR
     ERDRDRDRER KLSNTSIAEP AVAVRSSIAD ARGTLQLGYD TDSGSEKQDR ETEKYSMRRQ
     ASVDNVPTVS AHNLSNASSP LPQARNKQHS SDKDYSHSVA DTYNDARSSA YDPESTPVRK
     SSTSSMPASP AAWQLEVGDE DMRSLENATK LSTIRMKLEE KRRRIEQDKR KIEMALLRHQ
     EKEDLESCPE VMKWETMSNE SKRTPDMDPV DLDKYQQSIA IMNMNLQDIQ QDIHRLATQQ
     SQMQAQHLQA QQLLQAQQIA NMLNQAYNAP VSAYSSRPPS RDPYQQQHQQ QQPMAMPQPM
     QFVNEHGQYM SPPQPSHYQP QSIYSDNGAP YNNHSPHYGA AAPPQYRSSV VFDDYGQPTN
     HFYLHESSPQ AQPQGHPQRR TWAHSAAAAA YEQQQQIQQP MVDVNAWQSQ QQQQQHHQQQ
     KKAQQPWMNR PPSSAGGAAQ GSFMLHQNGG GGGGGGGGEL QHLFQVQASP QHSQRQLGGG
     ANGVQRQQSL TNLRDNRSPK SQHQPQTMGM AMQQEDMMAP QSICFIGDEE DVDEVERNII
     ESMQATRISD FVLQQQQQQQ HHQQQLQLQQ QQQRLQGGRG SSSEDYDSGE MISNKLNITS
     GNLTYRIPSP SRPSIQANSF QDPRDSEDQP AEKGFYISFD DDQPKRPKPP LRAKRSPKKE
     ALPLGGSSSS IRDRDSVDHQ TLLKRESLSQ LHNNNNNNGS EDGHKSAGAN RHSIHGLNHS
     NSVKSPGNAT YNKYTDEAPI QLRHLAVSGS DPFGHEPHPH PHPQPMQQQP MSPTRIQQSN
     NSAEAAKNKA LVIGADATNL DPESVDEMER RKEKIMLLSL QRRQQQEEAK ARKEIEASQK
     REKEREKEEE RARKKEDQMA RRAAILEQHR LKKAIEEAER EGKTLDRPDL HVKLQPQSSS
     ATNPRLRQQR TTRPRPKTIH VDDASVDISE ASSISSRGKK GSSSNLTGYG QLSSNSMKRD
     YYRGSQDSLT VKESPDDYPS TSSTPIGRRG SYKTSREPAA VERGRTLSRI SVAKGSTLNF
     RGRKSNSLMN LCGPKLYKQP AAKSNRGIIL NAVEYCVFPG AVNREAKQKV LEKIARSEAK
     HFLVLFRDAG CQFRALYSYM PESGDQVTKL YGTGPSQVDE VMFDKFFKYN SGGKCFSQVH
     TKHLTVTIDA FTIHNSLWQG KRVQLPSKKD MALVI
//
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