ID   A0A0R3NUP1_DROPS        Unreviewed;      1272 AA.
AC   A0A0R3NUP1; A0A6I8V9R6;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 {ECO:0000313|RefSeq:XP_015036749.1};
GN   Name=LOC4816419 {ECO:0000313|RefSeq:XP_015036749.1};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_015036749.1};
RN   [1] {ECO:0000313|RefSeq:XP_015036749.1}
RP   IDENTIFICATION.
RC   STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_015036749.1};
RC   TISSUE=Whole body {ECO:0000313|RefSeq:XP_015036749.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_015036749.1; XM_015181263.2.
DR   AlphaFoldDB; A0A0R3NUP1; -.
DR   STRING; 46245.A0A0R3NUP1; -.
DR   EnsemblMetazoa; FBtr0380672; FBpp0341047; FBgn0078284.
DR   GeneID; 4816419; -.
DR   InParanoid; A0A0R3NUP1; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0078284; Expressed in insect adult head.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:1901387; P:positive regulation of voltage-gated calcium channel activity; IEA:EnsemblMetazoa.
DR   CDD; cd12912; PDC2_MCP_like; 1.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   PANTHER; PTHR10166:SF37; VOLTAGE-DEPENDENT CALCIUM CHANNEL UNC-36; 1.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
SQ   SEQUENCE   1272 AA;  143714 MW;  0D7E3CA9CD925146 CRC64;
     MESKHWSCFV AIVLGVLIFK MHIFAALGDQ DEDIPHNEVR NWALKFGVDL WEFGRQFTKM
     NEIKNRFKDN DIEVKRKDGI ILLRELAAEV KNFMDFKRNA VMRLMDSAEQ AALSEMDGQG
     QAEGPLGGQQ QHYDARRINE YNADGKLADG ARHMDIRFMR RFERLPVNLS LSSILVPHGV
     DLDEADVKSA LQWSAHLDPL FQNNLEQDPA LSWQYFGSSS GFLRRFPGTA WPPEGSKGSK
     LIHDFRTHNW FVQAASSPKD IMILLDASSS MSEKSFDLGM ATAFNILDTL GEDDFVNLIT
     FSEVVKAPVP CFKDRMVRAT PDNIQEIKSA VKAIKLQDTA NFTAGLEYAF SLLHKYNQSG
     SGSQCNQAIM LITESTSESH KDIIKQYNWP HMPVRIFTYL IGSDSSSRSN LHDMACSNKG
     FFVQINDYEE ARRKVIDYAL VMARPMIMYQ ADHPVHWSPV FVAGKSGGLG RDSEYQRRLV
     TTVSTPVFDR RNHSVRVANL LGVVGTDVPI EEIRKVIPQH KLGPNGYSFI VDNNGRVLYH
     PDLRPLGDGN QYIDQLKPKY ASVDITELEL PETEIGNDHE LVEMNKNLLN EMRSDMIRPK
     EGETEFTILN HYDEVKRVST RTHRYFYGPI EDTPFTLAIV LPEKYGSHEL VSQQEIRHSR
     NNVTEYFKGD NWRVHPEWVY CEYNSVSDLE KERESSGEYS SRDQEPSFGS PEEQVLHFLA
     RAGRPGWKWM SVRPKSPQPH HNMHSGSNGN SPGSSHFGSQ HLNAQGSRKA EPYFCDRTLI
     QSLVRDAMVT DGLDRNTTSP SNGKEDKHPI ATLMAILKRQ GYSKFVVATS FVATRSGLLR
     WIDHIKRPED TPEPHFSEDN VRAMDTSWYK RAIDQHAVEP DSFVYSVPFG SGYAIKSNAT
     LVTASHAIFV EHRGHKAPAG VVGLQFQHDS LAKHFINITS TCTAAGASGC KRTCASDNLD
     CYVLDNSGFV IISEEMEHTG KFFGQIDGTI MDSLVQDRIY KRVTVNDFQG VCSDADNPYT
     AAGGILKPNR LGSWFFNHLV ALSATWLSFM PATLRAWPQD DYTYDNEDVV FVENNYSDEY
     DNFDNDYGLP VDQEMDEFFT TADVEYTTPP PKVHKPHAGP RFAPDPQNAR RCDLRTDLYM
     LQPERLTQGG QNNPLKGKLT NCHVSGCERP FSVQKIPHSN LILLVVDTLC PCGSKQLDIE
     PLEESGVVGA CSTRRQTQEQ ESRRRPRKCI NYHPEEIEIQ QCGRGSNLSH MSISVVVAHI
     LMVAVTFVLS NA
//