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Database: UniProt
Entry: A0A0R3NXW7_DROPS
LinkDB: A0A0R3NXW7_DROPS
Original site: A0A0R3NXW7_DROPS 
ID   A0A0R3NXW7_DROPS        Unreviewed;      1595 AA.
AC   A0A0R3NXW7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   31-JUL-2019, entry version 15.
DE   SubName: Full=Uncharacterized protein, isoform D {ECO:0000313|EMBL:KRT05922.1};
GN   Name=Dpse\GA22812 {ECO:0000313|EMBL:KRT05922.1};
GN   ORFNames=Dpse_GA22812 {ECO:0000313|EMBL:KRT05922.1}, GA22812
GN   {ECO:0000313|FlyBase:FBgn0244214};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|EMBL:KRT05922.1, ECO:0000313|Proteomes:UP000001819};
RN   [1] {ECO:0000313|EMBL:KRT05922.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000313|EMBL:KRT05922.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH379063; KRT05922.1; -; Genomic_DNA.
DR   RefSeq; XP_015040985.1; XM_015185499.1.
DR   SMR; A0A0R3NXW7; -.
DR   EnsemblMetazoa; FBtr0366661; FBpp0329774; FBgn0244214.
DR   GeneID; 6901910; -.
DR   FlyBase; FBgn0244214; Dpse\GA22812.
DR   Proteomes; UP000001819; Partially assembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819}.
FT   DOMAIN      252    320       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      365    419       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      426    480       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      482    547       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      604    777       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      778    938       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1381   1586       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      576    602       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      951    970       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1015   1035       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1078   1102       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1175   1198       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1229   1251       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED     1333   1378       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1175   1189       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1595 AA;  181556 MW;  16F047300A23F650 CRC64;
     MRQFNISVIG LSGTEKDRGQ VGVGKSCLCN RFMRPMADDY FIDHISVLSQ SDFSGRIVNN
     DHFLYWGEVR KTTDEGVEYN FNIIEQTEFM DDSTFQAFKV GKMDPYSKRC TATKVFSAEK
     LMYICKNQLG IEKEYEQKVM PDGRLSIDGF VVVFDVSPVP NRSVEKQVEF VQNVIATIVK
     NKKPLVLVTT KNDDAYELYV REAEKISQRK DYKSTVQLIE TSAHESINID LAFLMLAQMI
     DKVKNRVKII SYQESAKSRK ELLDTRSEAV TRLIRNQITD YHILWSQGSK MLSQYREWNE
     FLNIFGHEAG QKLFRRHMKK LRDDHLNKKL HQYLDKFALA LEYMLPDTGA LNISDDDAWE
     CARNYLQNHI EFEQYFFECP QASWTELVDM DEAEDEARIP FDVLETSEAE TVFRNYLNSV
     QQDKKKIGWK QQFKMLLEES GFVTPGKQLS EVRVLFMGRE CFEALSEHDC QQIYDIHQDE
     IIEKSKQNFV ELLLEHAQYF LQFKNVDIIT QEDVRQITDV IQEDSRYKML DRLDQERRVM
     LVQHLRFIHC PIRDHCPFFN NCVDSLIEEV LSDKSTTSNH KTPGGVGVGV GGGGGGGGWK
     TTGNGTDRTL NLLIVGSEHL ASDLLNDIRI CTGSKGEYIY ENQTYYLNYR IANGDMEAFK
     AIDVYSSGLI CVYSNQQSFE TLKDNLERTL LCNLELEDKF ENLPIVLVYQ PQDLKENEVE
     YLRSEGMRLS EMLHCDFIDH TQNHQKYVYD ILNIVILSLK LTEMKSYDPY PSNHTDLRIL
     CCIFCGDQYD IENIVQPLVA ESTLVKASEH SIIVDVFIGD AKRRVEFILS SYHGTNQYRD
     ELIHGYIYFY SAKRRSSLAN LSILAAQNAN IPLQIIAVTE SGGVNAFFNS DICQFLITEG
     NAVADRFKGS FMTFSADQYV KFAFYNPFLK TSWDNKYEVE NLHVEESITL DSGEGTLESS
     VNQMPRPPPR HESYMLSNTL GTDGSGSENY EMLPTRSLNS LNEERDISLD EIYDENNEKP
     KHLHQTDVSG SKDSLATHDA EWLEDKSDGR RNMNKNSIWN NFSGSTHAYT TGRRHIDSNL
     NKIRPKGPSQ TLKVGEAPSR NCPAMSSSTF TLPTQPPGKL NMKNFQLVSE AVAKMNFTGS
     GSGSGSGSGS GSGTGLGLCT GSGSMADSYL GDCEPVGKDG KRYDHAQLDG EDEDSEELAE
     YEQIYENEDC TESDSCASST ERRVRQQNAY FKASSKASKA SAKKQKKKKV AIPVQTPRVP
     PFGSYVSPPE IPLHYQRMAI VGAGEKKKTE AGVPEFMKSD KSPEYSMVPE LTAAGIFGAE
     NLPEYNMNAK CLKDFEKLEK RRIKEEAARL RKQQEKEKEQ EKKLKRKLKQ NAKGLAESVE
     AQFGKLMISS EQGEIPIFLN KCVEFIEKEG LDSEGIYRVP GSRAHVDMLF QRFEEDVNTV
     IDVLDIPVNA VATALKDFFS KRLPPLFSKD IIKELEEIAG SRGVGVGSSK LNVEVKTDRS
     CRLIALKSLL QKLPPINFAI LKYIFQHFVH VSDNSKLNSM DSKNLAICWW PTLIPIDFTD
     MGHFEQLRPY LEDIVQTMID QFPYLFCGKD AFVMV
//
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