ID   A0A0R3NZJ3_DROPS        Unreviewed;      1552 AA.
AC   A0A0R3NZJ3; A0A6I8V9B0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Multidrug resistance-associated protein 1 isoform X12 {ECO:0000313|RefSeq:XP_015036523.1};
GN   Name=LOC4816493 {ECO:0000313|RefSeq:XP_015036523.1};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_015036523.1};
RN   [1] {ECO:0000313|RefSeq:XP_015036523.1}
RP   IDENTIFICATION.
RC   STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_015036523.1};
RC   TISSUE=Whole body {ECO:0000313|RefSeq:XP_015036523.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_015036523.1; XM_015181037.2.
DR   SMR; A0A0R3NZJ3; -.
DR   EnsemblMetazoa; FBtr0375090; FBpp0336560; FBgn0079441.
DR   GeneID; 4816493; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0079441; Expressed in insect adult head and 2 other cell types or tissues.
DR   ExpressionAtlas; A0A0R3NZJ3; baseline.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd18595; ABC_6TM_MRP1_2_3_6_D1_like; 1.
DR   CDD; cd18603; ABC_6TM_MRP1_2_3_6_D2_like; 1.
DR   CDD; cd03250; ABCC_MRP_domain1; 1.
DR   CDD; cd03244; ABCC_MRP_domain2; 1.
DR   Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR005292; MRP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00957; MRP_assoc_pro; 1.
DR   PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR   PANTHER; PTHR24223:SF443; MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I; 1.
DR   Pfam; PF00664; ABC_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50929; ABC_TM1F; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ   SEQUENCE   1552 AA;  173906 MW;  8A465EED70632298 CRC64;
     MAEDIGSPMD RFCGSTFWNA TETWYTNNPD FTPCFEQTAL VWMPCAFYWA FVVFDFYYLK
     ASLDRNIPWN KLSVSKMLVN LGLLVITALD LIMALVKKGG DSELPLYDLD VWGPIIKFVT
     FLLIFIFIPL NRKYGVQTSG CQFIFWFLLT VLSIPRCRTE VRAAADRSKI DDSQQPSESD
     FSWEEYMYVS FFVSFTLYCC MLLLNCFADG QPTQTKYQRG ENEIPELSAS FLSRITYQWF
     DKMALKGYRN PLEEKHLWDL RPQDSCSEVM PIFAYHWNQN VRKNYKGRSK TEPKAQFSNG
     NVTFENPHGE KTGRKKGMAS IMPPIYKSFG GVFLFGALMK LITDTLTFAQ PQVLSLIIGF
     VEDQRTDPQP EWKGILFSVT LFVLAAAQTF ILGQYFHRMF IVGLRIRTAL INAIYRKALR
     ISNATKKEST VGEIVNLMAV DAQRFMELTT YLNMIWSAPL QIGLALYFLW QQLGPSVLAG
     LAVMIILIPV NGVIASRIKT YQIRQMKYKD ERVKLMNEVL SGIKVLKLYA WEPSFEKQVL
     DIRDKEIATL RSTAYLNAST SFLWSCAPFL VSLVTFATYV LTSEANQLSV EKVFVSLALF
     DIMKIPLTVL PMLTVDIAET QVSVKRINKF LNSEELDPNS VLHDSSKPHP MSIENGEFSW
     GDEITLRNIN IEVRKSNLVA LVGTVGSGKS SVVQAFLGEM EKLAGVVNTV GKMAYVPQQA
     WIQNATVRDN ILFGQQYDRK RYNKVIDACA LRADIDILSA GDLTEIGEKG INLSGGQKQR
     ISLARAVYCD ADLYLLDDPL SAVDSHVGKH IFEEVIGPKG LLARKSRILV THGVTFLPQV
     DSIYVLKMGE ISESGTFDQL VKNKGAFADF IIQHLQDGNA EEEELNQIKR QISSTGDVPE
     LLGSVEKAIK LARTESLSDS ISVTSADSLM GTGSGGSLRR RTRRQNSHDS VASAASLKKK
     QEVEGKLIET EKSQTGGVDF AVYKHYIKSV GIFLSVATLV LNFVFQAFQI GSNLWLTKWA
     NDENVGNDTG LRDMYLGVYG AFGFGQVSVS FFSSLAISLG CLECSRSLHT TLLYYNLRWP
     MELFDTTPLG RIVNRFSKDI DTIDNVLPFN IRVVLGQGFM VLATIVVISM STPIFLAVIV
     PIALLYYFAQ RFYVATSRQL MRLESVSRSP IYSHFGETVT GAPTIRAYNV GDRFIEESDA
     KVDKNQVCKY PSVIANRWLA IRLEMVGNLI ILFASLFAVL GGQTDPGLVG LSVSYALQVT
     QTLNWLVRMS SDIETNIVSV ERIKEYGETK QEAAWELEQD KDKPKHWPEE GRVEFQNFQV
     RYREGLDLVL RGVSFNITGG EKVGIVGRTG AGKSSLTLAL FRIIESAGGR IMIDGVDIAG
     MGLHMLRSRL TIIPQDPVLF SGSLRINLDP FEIKTDDEIW KALELSHLKS FVKSLTAGLN
     HEIAEGGENL SVGQRQLVCL ARALLRKTKL LVLDEATAAV DLETDDLIQK TIRTEFKECT
     VLTIAHRLNT ILDSDKVIVL DKGQITEFAS PTELLDNPKS AFYSMAKDAN LV
//