ID A0A0R3P023_DROPS Unreviewed; 1001 AA.
AC A0A0R3P023; A0A6I8VHV0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=LOC4814444 {ECO:0000313|RefSeq:XP_015041673.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_015041673.1};
RN [1] {ECO:0000313|RefSeq:XP_015041673.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_015041673.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_015041673.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR RefSeq; XP_015041673.1; XM_015186187.2.
DR AlphaFoldDB; A0A0R3P023; -.
DR EnsemblMetazoa; FBtr0375843; FBpp0337178; FBgn0070325.
DR GeneID; 4814444; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0070325; Expressed in insect adult head and 2 other cell types or tissues.
DR ExpressionAtlas; A0A0R3P023; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF83; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 385..412
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 461..480
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 542..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 586..608
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 762..789
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 810..833
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 162..371
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 374..949
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 1001 AA; 114695 MW; C07542049E7498E5 CRC64;
MDERESLYFD TISLADSEAA AAAAAHRKSL SQSRNTIYHS AVDLANDETR NSLRLGSGAA
AEHASLAWQP GYRQSTALEH LNGGGDQTDA AIAAQMLALH NGRNHLPTGI GVGGHTGAGA
GAGGGDDEVS RRLLRNSSTV SNKDKKLPIT YSQWKLRTYR RFDDGKRSVD FVLAYNGEDQ
VEDHRRKREI FEANLQREGL QLEHNKVQRV HFIKIHAPFE VLYRYAEILK IKVPLKPIPG
QDQIFDEAAP AFKSCFTRMC RSLFSSVQLN TELFPEREPR IHLEFSRNYL ELYDTEHPNF
FDDSTRYSII NFILQRQHFL EGEETVDNLG VEKLVQDGIY TCAYTLHDKA DRDRLLKEWA
NISKWKNLQP LDQIKDYFGA KVALYFAWLG FYTQMLIPIS IFGLLCFLYG FVTWSSDPIS
RDICEDSGTI MCPQCDRSCD YWRLNETCTS SKFNYLIDNN MTVVFALAMA IWSVTYLEFW
KRYSAGLVHR WGLTGFTHHV EHPRSQYLAK ISRSKRLAGN TQGTGILDPD VPFWSIKFLP
NFTSYSIMVL FICISVIAIA GIIIYRMAQR ASHSILGSEN SMTFKVMILP MTAGIIDLIV
ISLLDLVYSK LAVHLTNYEY CRTQTEYDES LTIKNYVFQF VNYYSSLFYI AFLKGKFVGY
PAKYNRVLGF RQEECNPGGC LMELCMQLVI IMAGKQAVNA IVEMLIPYLQ RTIKEMIYRH
GWYKSHKEQR LVPYNQFTED YNLLPAENNS LYVEYLEMVV QFGFITLFSL AFPLAPLLAL
LNNVIEVRLD AIKMLRFLRR PVGMRARDIG VWHNIMTVVT RIAVASSAMI IAFSTNLIPK
IVYAASTGDR ELNGYLNFTL AYFNTKDFQL QPLLGGSQFV NETECRYTEF RNAPTDDHPY
KRPMIYWKIL TGRLAFIVIY QNIINMLQGV LRWAVPDVSG RLLKRIKREN FLLREHIIEY
EKQHAMLQAQ TAVHIQQTKS QESSGLRQRH GAGDEDATSF V
//
