ID   A0A0R3P7H0_DROPS        Unreviewed;       595 AA.
AC   A0A0R3P7H0; A0A6I8VLY1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Nuclear hormone receptor HR78 isoform X1 {ECO:0000313|RefSeq:XP_015044053.1};
GN   Name=LOC4812265 {ECO:0000313|RefSeq:XP_015044053.1};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_015044053.1};
RN   [1] {ECO:0000313|RefSeq:XP_015044053.1}
RP   IDENTIFICATION.
RC   STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_015044053.1};
RC   TISSUE=Whole body {ECO:0000313|RefSeq:XP_015044053.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU004334}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000256|RuleBase:RU004334}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_015044053.1; XM_015188567.2.
DR   AlphaFoldDB; A0A0R3P7H0; -.
DR   STRING; 46245.A0A0R3P7H0; -.
DR   EnsemblMetazoa; FBtr0369744; FBpp0332256; FBgn0080170.
DR   GeneID; 4812265; -.
DR   InParanoid; A0A0R3P7H0; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0080170; Expressed in female reproductive system and 3 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0035002; P:liquid clearance, open tracheal system; IEA:EnsemblMetazoa.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24083:SF54; NUCLEAR HORMONE RECEPTOR HR78; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
SQ   SEQUENCE   595 AA;  65210 MW;  61300E46DAFA59ED CRC64;
     MEGVKVEAFI KAEEPRAMPL IGSGSGAAAA AAAAAAASLS VELCLVCGDR ASGRHYGAIS
     CEGCKGFFKR SIRKQLGYQC RGAMNCEVTK HHRNRCQFCR LQKCLASGMR SDSVQHERKP
     IVDRKESLNA SVGGGSSTSG SGGTSSSYIS SKSGYQQARG KQHTVKADTA ATPPVPSNAA
     TPFGLNDNLF GLNFAELTQT LMFATQQQQQ QQQQQQQQQQ QSGSYSPDLP KAEVDDDDDD
     SMDNSSTLCL QLLANSASNN NSQHLNFNAG EPTTTLPTTA TLGLIKSSLD MRVINKGLQL
     LQPIQHQLER IGGQGTSLSV KPECDSEAED SGTEDAVDPE LEHMDLDFDF CNRSDLMINE
     AVFDQELFTD AQCAFHVQPP TLVHSYLNIH YVCETGSRII FLTIHTLRKV PVFEQLDSHS
     QVKLLRSAWP ALMAVALAQC QGQLSASTII AQFIQSIRQL ADIDKSEPLK ISKMAHLTRA
     LHDFVQELQS QEVTDMEFGL LRLILLFNPS LLQQRKERQL RGYVRRVQLY ALTSLRRQGG
     VGGEERFNCL VARLLPLSSL DAEAMEELFF ANLVGQMQME ALIPFILMTS NSIGL
//